7-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Names

[ CAS No. ]:
144485-80-3

[ Name ]:
7-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
493.6ºC at 760 mmHg

[ Molecular Formula ]:
C14H12ClN3O2

[ Molecular Weight ]:
289.71700

[ Flash Point ]:
252.3ºC

[ Exact Mass ]:
289.06200

[ PSA ]:
60.92000

[ LogP ]:
2.89790

[ Vapour Pressure ]:
6.96E-10mmHg at 25°C

[ Index of Refraction ]:
1.667

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2492020
CHEMICAL NAME :
4(3H)-Quinazolinone, 7-chloro-2-ethyl-3-(3-methyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
144485-80-3
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H12-Cl-N3-O2
MOLECULAR WEIGHT :
289.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • (6-Cyclohexylpiperidin-3-yl)methanamine
  • 4-(1-(p-Tolyloxy)ethyl)benzoic acid
  • 1-(Oxetan-3-yl)piperidine-4-carboxylic acid
  • 3-Amino-5-ethoxyphenol
  • 3-[3,5-Bis(trifluoromethyl)phenyl]-3-hydroxypropanenitrile
  • 2-Bromo-1-(3-bromo-2-methylphenyl)ethanone
  • 1-Bromo-4-phenoxybutan-2-one
  • 1-Bromo-4-(oxolan-2-yl)butan-2-one
  • N-(furan-2-ylmethyl)-N-((1-methyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide
  • CID 87659591
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