7-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one

Names

[ CAS No. ]:
144485-81-4

[ Name ]:
7-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
557.6ºC at 760mmHg

[ Molecular Formula ]:
C18H12ClN3O2

[ Molecular Weight ]:
337.76000

[ Flash Point ]:
291ºC

[ Exact Mass ]:
337.06200

[ PSA ]:
60.92000

[ LogP ]:
4.00250

[ Vapour Pressure ]:
1.81E-12mmHg at 25°C

[ Index of Refraction ]:
1.69

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2807010
CHEMICAL NAME :
4(3H)-Quinazolinone, 7-chloro-3-(3-methyl-5-isoxazolyl)-2-phenyl-
CAS REGISTRY NUMBER :
144485-81-4
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H12-Cl-N3-O2
MOLECULAR WEIGHT :
337.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-chloro-2-nitrobenzoyl chloride
  • 2-amino-4-chloro-N-(3-methyl-1,2-oxazol-5-yl)benzamide
  • (Triethoxymethyl)benzene

DownStream

Related Compounds

  • 5-[2-(Hydroxymethyl)morpholin-4-YL]furan-2-carbaldehyde
  • 2-Isopropyl-3-nitrobenzaldehyde
  • 1-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-(methylamino)ethan-1-one
  • 2-{1h,4h,5h,6h-Cyclopenta[c]pyrazol-3-yl}propan-1-amine
  • 2-{1H,4H,5H,6H-cyclopenta[c]pyrazol-3-yl}ethan-1-ol
  • 6-Fluoro-1-methoxy-isoquinoline-3-carboxylic acid
  • (R)-2-(3-(Fluoromethyl)pyrrolidin-1-yl)ethanol
  • 2-N-(3-Methylphenyl)pyridine-2,6-diamine
  • Benzonitrile, 3-[(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methyl]-4-methoxy-
  • 4-Fluoro-3-(piperazin-1-yl)benzo[d]isoxazole
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