6-chloro-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Names

[ CAS No. ]:
144485-82-5

[ Name ]:
6-chloro-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
490ºC at 760mmHg

[ Molecular Formula ]:
C12H8ClN3O2

[ Molecular Weight ]:
261.66400

[ Flash Point ]:
250.1ºC

[ Exact Mass ]:
261.03100

[ PSA ]:
60.92000

[ LogP ]:
2.33550

[ Vapour Pressure ]:
9.53E-10mmHg at 25°C

[ Index of Refraction ]:
1.702

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2806000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-chloro-3-(3-methyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
144485-82-5
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H8-Cl-N3-O2
MOLECULAR WEIGHT :
261.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • Methyl 2-amino-5,6,7,8-tetrahydroquinazoline-6-carboxylate
  • 4-(4-Methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carboxaldehyde
  • 2-(7-Oxoazepan-4-yl)acetic acid
  • 3-(1-Methyl-7-oxoazepan-4-yl)propanoic acid
  • (2-Amino-3-methoxyphenyl)-1H-pyrazol-4-ylmethanone
  • tert-Butyl ((6-phenylpiperidin-3-yl)methyl)carbamate
  • 5-(4-Aminobutan-2-yl)-2-methoxyphenol
  • 4-(4-Aminobutan-2-yl)-2-methoxyphenol
  • Methyl 2-phenylcyclobutane-1-carboxylate
  • 5-(Bromomethyl)-3-(4-bromophenyl)-4,5-dihydroisoxazole
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