6-chloro-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Names

[ CAS No. ]:
144485-82-5

[ Name ]:
6-chloro-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
490ºC at 760mmHg

[ Molecular Formula ]:
C12H8ClN3O2

[ Molecular Weight ]:
261.66400

[ Flash Point ]:
250.1ºC

[ Exact Mass ]:
261.03100

[ PSA ]:
60.92000

[ LogP ]:
2.33550

[ Vapour Pressure ]:
9.53E-10mmHg at 25°C

[ Index of Refraction ]:
1.702

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2806000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-chloro-3-(3-methyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
144485-82-5
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H8-Cl-N3-O2
MOLECULAR WEIGHT :
261.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • 2-(2-Bromo-5-hydroxy-4-methoxyphenoxy)acetic acid
  • 5-(Azetidin-3-yloxy)-4-bromo-2-methoxyphenol
  • 4-Bromo-2-methoxy-5-(pyrrolidin-3-yloxy)phenol
  • 4-bromo-2-[(2S)-2-hydroxypropyl]-6-methoxyphenol
  • 2-(3-Bromopropyl)-4,5,6,7-tetrahydro-1-benzothiophene
  • 2-(3-Bromoprop-1-en-2-yl)-4,5-dimethylphenol
  • 2-(3-Bromopropyl)-4,5-dimethylphenol
  • 1-(3-Bromo-2,2-dimethylpropyl)-3-methoxy-2-methylbenzene
  • 2-Amino-1-(5-bromo-3-fluoro-2-hydroxyphenyl)propan-1-one
  • 2-(3-Amino-1-hydroxypropyl)-4-bromo-6-fluorophenol
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