6-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Names

[ CAS No. ]:
144485-84-7

[ Name ]:
6-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
493.6ºC at 760mmHg

[ Molecular Formula ]:
C14H12ClN3O2

[ Molecular Weight ]:
289.71700

[ Flash Point ]:
252.3ºC

[ Exact Mass ]:
289.06200

[ PSA ]:
60.92000

[ LogP ]:
2.89790

[ Vapour Pressure ]:
6.96E-10mmHg at 25°C

[ Index of Refraction ]:
1.667

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2492000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-chloro-2-ethyl-3-(3-methyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
144485-84-7
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H12-Cl-N3-O2
MOLECULAR WEIGHT :
289.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • 3-(4-Methoxyphenyl)-2,5,6-trimethyl-1H-indole
  • 4-(6-Bromo-[1,2,4]triazolo[1,5-A]pyridin-2-YL)morpholine
  • 4-Methoxy-3-(5-methyl-1H-pyrazol-1-YL)benzaldehyde
  • 2,3-Dihydro-5-(methylthio)-1H-isoindole
  • 5,5-Difluoro-3-(fluoromethyl)-4,5,6,6A-tetrahydro-3AH-cyclopenta[D]isoxazole
  • 5,5-Difluoro-3-methyl-4,5,6,6A-tetrahydro-3AH-cyclopenta[D]isoxazole
  • 5-Azaspiro[3.4]octan-7-ylmethanol
  • 5'-Chloro-1'-methylspiro[cyclopropane-1,3'-indolin]-2'-one
  • 5-Chloro-2-(4-chlorophenyl)oxazolo[5,4-B]pyridine
  • 5-Chloro-2-(4-fluorophenyl)oxazolo[5,4-B]pyridine
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