6-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Names

[ CAS No. ]:
144485-84-7

[ Name ]:
6-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
493.6ºC at 760mmHg

[ Molecular Formula ]:
C14H12ClN3O2

[ Molecular Weight ]:
289.71700

[ Flash Point ]:
252.3ºC

[ Exact Mass ]:
289.06200

[ PSA ]:
60.92000

[ LogP ]:
2.89790

[ Vapour Pressure ]:
6.96E-10mmHg at 25°C

[ Index of Refraction ]:
1.667

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2492000
CHEMICAL NAME :
4(3H)-Quinazolinone, 6-chloro-2-ethyl-3-(3-methyl-5-isoxazolyl)-
CAS REGISTRY NUMBER :
144485-84-7
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H12-Cl-N3-O2
MOLECULAR WEIGHT :
289.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Chloro-2-nitrobenzoyl chloride

DownStream

Related Compounds

  • 3-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(2S)-1-(prop-2-yn-1-yl)pyrrolidine-2-carbonyl]piperidine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • N-(1H-benzimidazol-2-ylmethyl)-4-hydroxyquinoline-3-carboxamide
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • Methyl 5-(aminomethyl)-2-(trifluoromethyl)benzoate hydrochloride