2,3-Dihydrophthalazine-1,4-dione

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Names

[ CAS No. ]:
1445-69-8

[ Name ]:
2,3-Dihydrophthalazine-1,4-dione

[Synonym ]:
1,4-Phthalazinedione
1,4-DIHYDROXYPHTHALAZINE
Phthalohydrazide
N,N'-Phthaloylhydrazine
2,3-DIHYDRO-PHTHALAZINE-1,4-DIONE
1,4-phthalazinediol
2,3-dihydrophthalazine-1,4-dione
2,3-Dihydro-1,4-phthalazinedione
Phthalhydrizide
PHTHALHYDRAZINE
PHTHALIC HYDRAZIDE
PHTALYLHYDRAZINE
phthalazine-1,4-diol
Phthalodihydrazide
1,4-Phthalazinedione, 2,3-dihydro-
2,3-Dihydro-1,4-phthalazinedione ; Phthalhydrazine
EINECS 215-893-4
MFCD00006888
1,4-Ketophthalazine
Phthaloylhydrazine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
523.5ºC at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C8H6N2O2

[ Molecular Weight ]:
162.145

[ Flash Point ]:
270.4ºC

[ Exact Mass ]:
162.042923

[ PSA ]:
65.72000

[ LogP ]:
0.57

[ Vapour Pressure ]:
1.41E-11mmHg at 25°C

[ Index of Refraction ]:
1.587

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TH8890080
CHEMICAL NAME :
1,4-Phthalazinedione, 2,3-dihydro-
CAS REGISTRY NUMBER :
1445-69-8
LAST UPDATED :
199509
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H6-N2-O2
MOLECULAR WEIGHT :
162.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 327,237,1994 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
700 mg/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 327,237,1994

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TH8890080

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

  • dihydralazine
  • 4-Bromophthalazin-1(2H)-one
  • 1,4-dibromophthalazine
  • N,N-bis[(2-chlorophenyl)methylideneamino]phthalazine-1,4-diamine
  • Benzaldehyde, 2,6-dichloro-, 1,4-phthalazinediyldihydrazone(8CI,9CI)
  • 2-Propenal, 3-phenyl-,1,4-phthalazinediyldihydrazone (9CI)
  • Benzaldehyde, 3-nitro-,1,4-phthalazinediyldihydrazone (9CI)
  • Benzaldehyde,4-chloro-, 1,4-phthalazinediyldihydrazone (9CI)
  • 4-CHLORO-1,2-DIHYDROPHTHALAZIN-1-ONE
  • 1-Chloro-4-hydrazinophthalazine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of 2,3-dihydrophthalazine-1,4-dione on Sprague Dawley rats lipid metabolism and serum lipoproteins.

Biomed. Biochim. Acta 47(4-5) , 423-33, (1988)

2,3-Dihydrophthalazine-1,4-dione effectively lowers serum levels of cholesterol and triglycerides in Sprague Dawley rats after two weeks, after which the cholesterol levels continued to decline. The m...

Anti-inflammatory activity of 2,3-dihydrophthalazine-1,4-diones in CF1 mice.

Int. J. Tissue React. 18(2-3) , 47-55, (1996)

2,3-Dihydrophthalazine-1,4-diones were observed to be potent anti-inflammatory agents as well as capable of protecting against endotoxin shock in mice at 8 mg/kg i.p. These agents blocked both locally...

The anti-neoplastic activity of 2,3-dihydrophthalazine-1,4-dione and N-butyl-2,3-dihydrophthalazine-1,4-dione in human and murine tumor cells.

Anticancer Drugs 3(1) , 55-62, (1992)

2,3-Dihydrophthalazine-1,4-dione derivatives demonstrated potent cytotoxicity against the growth of murine leukemia cells and human single cell suspension, i.e. Tmolt3 leukemia and HeLa-S3, as well as...


More Articles

Related Compounds

  • 2,3-dihydrophthalazine-1,4-dione
  • 6-azido-2,3-dihydrophthalazine-1,4-dione
  • 6-bromo-2,3-dihydrophthalazine-1,4-dione
  • 5-Amino-2,3-dihydrophthalazine-1,4-dione
  • 5-Nitro-2,3-dihydrophthalazine-1,4-dione
  • 5-amino-2,3-dihydrophthalazine-1,4-dione