(R)-1-Boc-2-cyanopyrrolidine

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Names

[ CAS No. ]:
144688-70-0

[ Name ]:
(R)-1-Boc-2-cyanopyrrolidine

[Synonym ]:
tert-Butyl 2-cyanopyrrolidine-1-carboxylate
2-Methyl-2-propanyl (2S)-2-cyano-1-pyrrolidinecarboxylate
1-Boc-2-cyano-pyrrolidine
tert-Butyl-2-cyanpyrrolidin-1-carboxylat
MFCD01861224
1-Pyrrolidinecarboxylic acid, 2-cyano-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 2-cyano-1-pyrrolidinecarboxylate
(R)-1-Boc-2-cyanopyrrolidine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
307.9±35.0 °C at 760 mmHg

[ Melting Point ]:
33-36ºC(lit.)

[ Molecular Formula ]:
C10H16N2O2

[ Molecular Weight ]:
196.246

[ Flash Point ]:
140.0±25.9 °C

[ Exact Mass ]:
196.121185

[ PSA ]:
53.33000

[ LogP ]:
0.40

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.489

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Tosyl cyanide
  • 2-Methyl-2-propanyl 1-pyrrolidinecarboxylate
  • tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate
  • Trimethylsilyl cyanide
  • tert-butyl 2-methoxypyrrolidine-1-carboxylate
  • Boc-L-Proline

DownStream

  • tert-Butyl 2-(N-hydroxycarbamimidoyl)pyrrolidine-1-carboxylate
  • tert-butyl 2-(2-chloroethyl)-2-cyanopyrrolidine-1-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • (R)-1-Boc-2-(methylaminomethyl)-4,4-difluoropyrrolidine
  • (R)-tert-Butyl 2-((R)-1-hydroxyethyl)piperazine-1-carboxylate
  • (R)-1-Boc-2-acetyl-piperidine
  • (R)-1-BOC-2-([(2-TRIFLUOROMETHYL-PHENYL)-AMINO]-METHYL)-PYRROLIDINE
  • (R)-1-BOC-2-([(4-TRIFLUOROMETHYL-PHENYL)-AMINO]-METHYL)-PYRROLIDINE
  • (R)-1-BOC-2-([(3-TRIFLUOROMETHYL-PHENYL)-AMINO]-METHYL)-PYRROLIDINE