5-[[4-(2-ethoxyphenyl)piperazin-1-yl]methyl]-4,5-dihydro-1,3-oxazol-2-amine

Names

[ CAS No. ]:
144881-48-1

[ Name ]:
5-[[4-(2-ethoxyphenyl)piperazin-1-yl]methyl]-4,5-dihydro-1,3-oxazol-2-amine

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
462.7ºC at 760mmHg

[ Molecular Formula ]:
C16H24N4O2

[ Molecular Weight ]:
304.38700

[ Flash Point ]:
233.6ºC

[ Exact Mass ]:
304.19000

[ PSA ]:
60.82000

[ LogP ]:
1.56190

[ Vapour Pressure ]:
9.68E-09mmHg at 25°C

[ Index of Refraction ]:
1.618

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6746500
CHEMICAL NAME :
2-Oxazolamine, 4,5-dihydro-5-((4-(4-methoxyphenyl)-3-methyl-1-pipera zinyl)methyl)-
CAS REGISTRY NUMBER :
144881-48-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H24-N4-O2
MOLECULAR WEIGHT :
304.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
524 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 27,437,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(4-METHOXYPHENYL)-2-METHYLPIPERAZINE, 1:1 MIXTURE OF CONFORMERS
  • cyanamide,sodium

DownStream

Related Compounds

  • Methyl 3-(4-{[(2,2,2-trifluoroethyl)sulfonyl]amino}phenoxy)-2-thiophenecarboxylate
  • 3-{4-[(2,2-Dimethylpropanoyl)amino]phenoxy}-2-thiophenecarboxylic acid
  • Carbamic acid, (3-nitrophenyl)-, 3-ethyl-5-methylphenyl ester
  • 3-(4-{[(4-Methoxyphenyl)sulfonyl]amino}phenoxy)-2-thiophenecarboxylic acid
  • 2-(Bicyclo[2.2.1]heptan-2-yl)acetaldehyde
  • (2R)-4-phenyl-2,3-dihydro-1H-inden-2-ol
  • diethyl 2-({[3-(3,4-dimethoxyphenethyl)-2,4-dioxo-3,4-dihydro-2H-1,3-benzoxazin-6-yl]amino}methylene)malonate
  • (E)-1,2-bis(4-methoxyphenyl)-3-[4-(trifluoromethyl)anilino]-2-propen-1-one
  • [3-methyl-6-(naphthalen-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
  • 5-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-methoxybenzenesulfonamide
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