5-[[4-(2-ethoxyphenyl)piperazin-1-yl]methyl]-4,5-dihydro-1,3-oxazol-2-amine

Names

[ CAS No. ]:
144881-48-1

[ Name ]:
5-[[4-(2-ethoxyphenyl)piperazin-1-yl]methyl]-4,5-dihydro-1,3-oxazol-2-amine

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
462.7ºC at 760mmHg

[ Molecular Formula ]:
C16H24N4O2

[ Molecular Weight ]:
304.38700

[ Flash Point ]:
233.6ºC

[ Exact Mass ]:
304.19000

[ PSA ]:
60.82000

[ LogP ]:
1.56190

[ Vapour Pressure ]:
9.68E-09mmHg at 25°C

[ Index of Refraction ]:
1.618

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6746500
CHEMICAL NAME :
2-Oxazolamine, 4,5-dihydro-5-((4-(4-methoxyphenyl)-3-methyl-1-pipera zinyl)methyl)-
CAS REGISTRY NUMBER :
144881-48-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H24-N4-O2
MOLECULAR WEIGHT :
304.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
524 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 27,437,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(4-METHOXYPHENYL)-2-METHYLPIPERAZINE, 1:1 MIXTURE OF CONFORMERS
  • cyanamide,sodium

DownStream

Related Compounds

  • Tert-butyl 2-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate
  • Tert-butyl 3-piperazin-1-yloxetane-3-carboxylate
  • 4-(Difluoromethyl)-2-fluoro-3-methoxybenzoic acid
  • 5-Formyl-4-methoxycarbonylfuran-2-carboxylic acid
  • 3-Bromoimidazo[1,5-a]pyrimidine-6-carbaldehyde
  • (2R)-3-(5-Fluoropyridin-3-yl)-2-methylpropanoic acid
  • 3-[Methyl(phenylmethoxycarbonyl)amino]cyclobutane-1-carboxylic acid
  • 3-Bromo-2-(difluoromethyl)imidazo[1,2-a]pyridine
  • 1-(Difluoromethyl)isoquinoline-5-carboxylic acid
  • 5-{[(Tert-butoxy)carbonyl]amino}-1,2-oxazole-4-carboxylic acid
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