20(R)-Hydroxypregn-4-en-3-one

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Names

[ CAS No. ]:
145-15-3

[ Name ]:
20(R)-Hydroxypregn-4-en-3-one

[Synonym ]:
20beta-Dihydroprogesterone
4-pregnen-20B-ol-3-one
EINECS 205-650-0
4-PREGNEN-20-β-OL-3-ONE
20(R)-Hydroxypregn-4-en-3-one

Chemical & Physical Properties

[ Density]:
1.09 g/cm3

[ Boiling Point ]:
451.7ºC at 760 mmHg

[ Molecular Formula ]:
C21H32O2

[ Molecular Weight ]:
316.47800

[ Flash Point ]:
192.4ºC

[ Exact Mass ]:
316.24000

[ PSA ]:
37.30000

[ LogP ]:
4.51530

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5560000
CHEMICAL NAME :
Pregn-4-en-3-one, 20-beta-hydroxy-
CAS REGISTRY NUMBER :
145-15-3
LAST UPDATED :
199206
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H32-O2
MOLECULAR WEIGHT :
316.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
35 mg/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Progesterone
  • pregn-4-ene-3,20-diol
  • Pregnenolone
  • cholesterol

DownStream

  • Progesterone

Related Compounds

  • 7-[(Dibutylamino)methyl]-6-hydroxy-2-(3-pyridylmethylene)benzo[b]furan-3-one
  • ethyl (2E)-3-(3-methoxyphenyl)but-2-enoate
  • 2,4,5-Trichlorophenyl decanoate
  • (3S,3'S,4'R)-Idoxanthin
  • N-[2-({[3-(4-morpholinyl)propyl]amino}carbonyl)phenyl]nicotinamide
  • (R)-3-Hydroxy-4-phenylbutanoic acid
  • 4-(((Tert-butyldimethylsilyl)oxy)methyl)-2-chloro-3-methylpyridine
  • 4-Phenylfluoren-9-one
  • 4-(4-methylphenyl)-3-[[4-(4-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazole-5-thione
  • 4-Methyl-5-trimethylsilylthiophene-2-carbaldehyde
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