5'-Bromo-2'-hydroxyacetophenone

Suppliers

Names

[ CAS No. ]:
1450-75-5

[ Name ]:
5'-Bromo-2'-hydroxyacetophenone

[Synonym ]:
Ethanone, 1-(5-bromo-2-hydroxyphenyl)-
1-(5-Bromo-2-hydroxyphenyl)ethanone
2-Acetyl-4-bromophenol
MFCD00191850

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
282.6±25.0 °C at 760 mmHg

[ Melting Point ]:
58-61ºC

[ Molecular Formula ]:
C8H7BrO2

[ Molecular Weight ]:
215.044

[ Flash Point ]:
124.7±23.2 °C

[ Exact Mass ]:
213.962936

[ PSA ]:
37.30000

[ LogP ]:
3.11

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.592

[ Water Solubility ]:
Soluble in Chloroform

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5556350
CHEMICAL NAME :
Ethanone, 1-(5-bromo-2-hydroxyphenyl)-
CAS REGISTRY NUMBER :
1450-75-5
BEILSTEIN REFERENCE NO. :
2045140
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H7-Br-O2
MOLECULAR WEIGHT :
215.06

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. (Publications & Information Directorate, Council of Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012, India) V.14B- 1976- Volume(issue)/page/year: 20,480,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
KM5556350

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Bromophenol acetate
  • Ortho-Hydroxyacetophenone
  • Phenyl 2-bromoacetate
  • 1-(5-Bromo-2-methoxyphenyl)ethanone
  • 4-Bromophenol
  • 2-hydroxy-5-bromoacetophenone oxime
  • 4-Bromoanisole
  • Acetyl chloride
  • Ethanoic anhydride
  • acetic acid

DownStream

  • 3,6-dibromo-2-phenylchromen-4-one
  • 2-Acetyl-4-cyanophenol
  • 6-bromo-3-formylchromone
  • 1-(5-Bromo-2-hydroxyphenyl)-3-phenyl-1,3-propanedione
  • 6-bromo-4-hydroxycoumarin
  • 6,4'-DIBROMOFLAVONE
  • 6-bromo-2-pyridin-4-ylchromen-4-one
  • 6-Bromo-4'-hydroxyflavone
  • 1-(5-bromo-2-hydroxy-3-iodophenyl)ethanone
  • METHYL 3-ETHYL-4-HYDROXYBENZOATE

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

N'-[1-(5-Bromo-2-hydroxy-phen-yl)ethyl-idene]-3,4,5-trihydroxy-benzohydrazide dimethyl sulfoxide solvate trihydrate.

Acta Crystallogr. Sect. E Struct. Rep. Online 66(Pt 3) , o721, (2010)

The benzohydrazide mol-ecule in the title compound, C(15)H(13)BrN(2)O(5)·C(2)H(6)OS·3H(2)O, is almost planar with an r.m.s. deviation for the non-H atoms of 0.078 Å. The organic mol-ecules, water and ...

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.

Bioorg. Med. Chem. Lett. 14(24) , 6083-7, (2004)

A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted chromenone libraries, which were screened as inhibitors of the DNA repair enzyme...

Spermicidal activity of oxovanadium(IV) complexes of 1, 10-phenanthroline, 2,2'-bipyridyl, 5'-bromo-2'-hydroxyacetophenone and derivatives in humans.

Biol. Reprod. 60(2) , 435-44, (1999)

We have recently reported that tetrahedral metallocene complexes containing vanadium(IV) (vanadocene) have potent spermicidal activity against human sperm. The spermicidal activity was dependent on va...


More Articles

Related Compounds

  • 1-(5-Bromo-4-fluoro-2-hydroxyphenyl)ethanone
  • 5'-bromo-3'-chloro-2'-hydroxyacetophenone
  • 5'-BROMO-2',3'-DIHYDRO-1'H-SPIRO[CYCLOPROPANE-1,4'-ISOQUINOLINE]
  • 5'-Bromo-2'-hydroxy-3',4'-benzo-α,β-dibromochalkone
  • 5'-Bromo-2'-hydroxy-4-methoxy-3',4'-benzochalkone α,β-dibromide
  • 5'-Bromo-2',4'-difluoroacetophenone
  • 1-(Dimethyl-1,3-thiazol-5-yl)ethane-1-sulfonamide
  • [2-(2-Aminoethyl)-1-piperidinyl]cyclobutylmethanone
  • 5-[(2-methoxyethyl)amino]-1,3-dimethyl-1H-pyrazole-4-carboxylic acid
  • 5-(cyclopropylamino)-1,3-dimethyl-1H-pyrazole-4-carboxylic acid
  • (3-(Thiophen-2-ylmethyl)-1,2,4-oxadiazol-5-yl)methanol
  • N-methyl-1-(3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanamine
  • 3-methyl-1-(3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)butan-1-amine
  • 5-(Cyclopentylamino)-1,3-dimethyl-1h-pyrazole-4-carboxylic acid
  • 1,3-dimethyl-5-(methylamino)-1H-pyrazole-4-carboxylic acid
  • (5-Bromo-1-isopropyl-1H-benzo[d]imidazol-2-yl)methanol
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.