Mitiglinide (Calcium)

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Names

[ Name ]:
Mitiglinide (Calcium)

[Synonym ]:
Mitiglinide
Mitiglinide calcium
MFCD08458378
(aS,3aR,7aS)-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt
[2(S)-cis]-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calclium salt
Mitiglinide hemicalcium salt
Mitiglinide (Calcium)

Chemical & Physical Properties

[ Density]:
1.175

[ Boiling Point ]:
519.6ºC at 760 mmHg

[ Melting Point ]:
146-148ºC

[ Molecular Formula ]:
C₁₉H₂₄NO₃Ca_0.5

[ Molecular Weight ]:
334.44

[ Flash Point ]:
268ºC

[ PSA ]:
102.45000

[ LogP ]:
5.59450

[ Vapour Pressure ]:
1.27E-11mmHg at 25°C

[ Storage condition ]:
room temp

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000

Articles

Efficacy and safety of mitiglinide versus nateglinide in newly diagnose patients with type 2 diabetes mellitus: a randomized double blind trial.

Diabetes Obes. Metab. 14(2) , 187-9, (2012)

This study was performed to examine the efficacy and safety of mitiglinide in type 2 diabetes patients (T2DM). Enrolled patients had received treatment with diet and exercise in the previous 3 months ...

Comparison of the rapidity of onset of the therapeutic effect between nateglinide and mitiglinide by PK/PD analysis in rats.

Eur. J. Drug Metab. Pharmacokinet. 37(1) , 9-15, (2012)

Nateglinide and mitiglinide are immediate short-acting insulinotropic agents. Both are administered preprandially to control postprandial hyperglycemia. Glinide drugs are characterized by immediate on...

Variations in tissue selectivity amongst insulin secretagogues: a systematic review.

Diabetes Obes. Metab. 14(2) , 130-8, (2012)

Insulin secretagogues promote insulin release by binding to sulfonylurea receptors on pancreatic β-cells (SUR1). However, these drugs also bind to receptor isoforms on cardiac myocytes (SUR2A) and vas...