(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt

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Names

[ CAS No. ]:
145781-92-6

[ Name ]:
(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt

[Synonym ]:
Goserelin acetate
Goserelin acetate [D-Ser(tBu)6,Azagly10]-LHRH acetate salt
Goserelin (acetate)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1695.5ºC at 760mmHg

[ Melting Point ]:
>190°C (dec.)

[ Molecular Formula ]:
C61H88N18O16

[ Molecular Weight ]:
1329.46

[ PSA ]:
493.39000

[ LogP ]:
-0.95

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.692

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 20 mg/mL, clear, colorless

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360

[ Precautionary Statements ]:
P201-P280-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OK6369800

Articles

Stability of peptide drugs in the colon.

Eur. J. Pharm. Sci. 78 , 31-6, (2015)

This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclo...

Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo.

Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 1277-83, (2015)

We report potent radiosensitization of prostate cancers in vitro and in vivo using goserelin-conjugated gold nanorods. Progressive receptor-mediated internalization of conjugated nanorods over time in...

Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.

Mol. Pharm. 12(3) , 966-73, (2015)

A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stabil...


More Articles


Related Compounds

  • (Glu1,D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
  • (Des-Pyr1,D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
  • (D-Ser4,D-Ser(tBu)6,AzaGly10)-LHRH trifluoroacetate salt
  • (Ser(Ac)4,D-Ser(tBu)6,AzaGly10)-LHRH trifluoroacetate salt
  • (Des-Gly10,D-His2,D-Ser(tBu)6,Pro-NHEt9)-LHRH acetate salt
  • (Des-Gly10,D-Tyr5,D-Ser(tBu)6,Pro-NHEt9)-LHRH acetate salt
  • benzyl N-{[6-(hydroxymethyl)-5-methyl-8-oxa-5-azaspiro[3.5]nonan-6-yl]methyl}carbamate
  • 2-{[(Tert-butoxy)carbonyl](3,3-dimethylcyclopentyl)amino}pyridine-3-carboxylic acid
  • benzyl N-[(1R)-2,2,2-trifluoro-1-[2-fluoro-4-(2-fluoroethoxy)phenyl]ethyl]carbamate
  • benzyl N-[4-cyano-1-(4-nitrophenyl)-1H-pyrazol-3-yl]carbamate
  • benzyl N-[4-cyano-1-(4-nitrophenyl)-1H-pyrazol-5-yl]carbamate
  • (3S)-3-{2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
  • Methyl 2-{[(benzyloxy)carbonyl]amino}-3-(4-chloro-2-nitrophenyl)propanoate
  • (2S)-3-(2-fluoro-5-iodophenyl)-2-{[(prop-2-en-1-yloxy)carbonyl]amino}propanoic acid
  • benzyl N-[(2-bromo-4-chlorophenyl)methyl]carbamate
  • 8-Fluoro-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid
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