Margatoxin

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Names

[ CAS No. ]:
145808-47-5

[ Name ]:
Margatoxin

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇₈H₂₈₆N₅₂O₅₀S₇

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.

Toxicology 289(1) , 11-8, (2011)

Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects ...

Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.

J. Phys. Chem. B 116(17) , 5132-40, (2012)

The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hK(v)1.3 wild-type and hK(v)1.3_H399N mutant potassium channels was...

Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.

Am. J. Physiol. Cell Physiol. 301(5) , C1186-200, (2011)

We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and biophysical properties with K(v)2.1 and K(v)2...

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