6-allyl-6,7-dihydro-5H-dibenz[c,e]azepine

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Names

[ CAS No. ]:
146-36-1

[ Name ]:
6-allyl-6,7-dihydro-5H-dibenz[c,e]azepine

[Synonym ]:
6-allyl-6,7-dihydro-5H-dibenzo[c,e]azepine
6-allyl-6,7-dihydro-5H-dibenz[c,e]azepine
Ilidar Base
Azapetine (BAN)
EINECS 205-667-3
Azapetine
Azapetina [Italian]
6-Allyl-6,7-dihydro-5H-dibenz<c,e>azepin
5H-DIBENZ(c,e)AZEPINE,6-ALLYL-6,7-DIHYDRO

Chemical & Physical Properties

[ Density]:
1.05g/cm3

[ Boiling Point ]:
364.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₇N

[ Molecular Weight ]:
235.32400

[ Flash Point ]:
157.1ºC

[ Exact Mass ]:
235.13600

[ PSA ]:
3.24000

[ LogP ]:
3.79310

[ Vapour Pressure ]:
1.67E-05mmHg at 25°C

[ Index of Refraction ]:
1.59

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HN7200000

CHEMICAL NAME :: 5H-Dibenz(c,e)azepine, 6-allyl-6,7-dihydro-

CAS REGISTRY NUMBER :: 146-36-1

BEILSTEIN REFERENCE NO. :: 0194617

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H17-N

MOLECULAR WEIGHT :: 235.35

WISWESSER LINE NOTATION :: T B676 IN JHJ I2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 98,702,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 725 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,2'-bis(bromomethyl)-1,1'-biphenyl
Allylamine

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

6-allyl-6,7-dihydro-5H-dibenz[c,e]azepine,dihydrogenphosphate
6-Allyl-6,7-dihydro-3,9-dichloro-5H-dibenz[c,e]azepine
6-Cyclohexyl-6,7-dihydro-5H-dibenz[c,e]azepine
6-Benzyl-6,7-dihydro-5H-dibenz(c,e)azepine
6-Butyl-6,7-dihydro-5H-dibenz[c,e]azepine
5H-Dibenz[c,e]azepine, 6,7-dihydro-
4-({3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}methyl)-1,3-oxazole
4-{3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}-5-fluoropyrimidine
4-({3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}methyl)-1-methyl-1,2-dihydropyridin-2-one
4-({3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}methyl)-2-methyl-1,3-thiazole
N-(2-methoxyphenyl)-3-{[(6-methylpyridazin-3-yl)oxy]methyl}pyrrolidine-1-carboxamide
1-(2-{3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}ethyl)-4-methyl-1H-pyrazole
4-({3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}methyl)-3,5-dimethyl-1,2-oxazole
2-({3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}methyl)-1,3,4-oxadiazole
5-({3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}methyl)-3-methyl-1,2,4-oxadiazole
5-[(2,4-dimethylphenyl)methyl]-1-methyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one

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