Yohimbine
Suppliers
Names
[ CAS No. ]:
146-48-5
[ Name ]:
Yohimbine
[Synonym ]:
[3H]-Yohimbine
Aphrosol
Methyl (16α,17α)-17-hydroxyyohimban-16-carboxylate
Yohimban-16α-carboxylic acid, 17α-hydroxy-, methyl ester (8CI)
corynine
yohimbine
(16α,17α)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester
quebrachine
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-
Quebrachin
Yohimbine HCl
(16a,17a)-17-Hydroxyyohimban-16-carboxylic Acid Methyl Ester
Yohimex
Yocon
APHRODINE
methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
MFCD00042748
Yohimban-16-α-carboxylic acid, 17-α-hydroxy-, methyl ester
EINECS 205-672-0
(+)-Yohimbin
Aphrodyne
Yohimbin
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
543.0±50.0 °C at 760 mmHg
[ Melting Point ]:
231-233 °C(lit.)
[ Molecular Formula ]:
C21H26N2O3
[ Molecular Weight ]:
354.443
[ Flash Point ]:
282.2±30.1 °C
[ Exact Mass ]:
354.194336
[ PSA ]:
65.56000
[ LogP ]:
2.20
[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C
[ Index of Refraction ]:
1.661
[ Storage condition ]:
Store at RT
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ZG1000000
- CHEMICAL NAME :
- Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy-, methyl ester
- CAS REGISTRY NUMBER :
- 146-48-5
- BEILSTEIN REFERENCE NO. :
- 0097276
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C21-H26-N2-O3
- MOLECULAR WEIGHT :
- 354.49
- WISWESSER LINE NOTATION :
- T F6 D5 C666 EM ON&&TTTJ TQ UVO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - paresthesis Behavioral - ataxia Cardiac - change in rate
- REFERENCE :
- AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 14,1002,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,432,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 16 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,432,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,432,1955
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1418,1935
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 11 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1418,1935 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - other effects on male
- REFERENCE :
- NLETDU Neuroendocrinology Letters. (Brain Research Promotion, D-7400, Tubingen, Germany) V.1- 1979- Volume(issue)/page/year: 12,69,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84715 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)
Safety Information
[ Hazard Codes ]:
T
[ Risk Phrases ]:
R23/24/25
[ Safety Phrases ]:
S27-S36/37/39-S45
[ RIDADR ]:
1544
[ RTECS ]:
ZG1000000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)