2-Fluoroadenosine

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Names

[ CAS No. ]:
146-78-1

[ Name ]:
2-Fluoroadenosine

[Synonym ]:
6-Amino-2-fluoro-9-(β-D-ribofuranosyl)purine
2-Fluoroadenosine
MFCD00866394
Adenosine, 2-fluoro-
Purine, 6-amino-2-fluoro-9-β-D-ribofuranosyl-
(2R,3R,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
747.3±70.0 °C at 760 mmHg

[ Melting Point ]:
240ºC

[ Molecular Formula ]:
C10H12FN5O4

[ Molecular Weight ]:
285.23

[ Flash Point ]:
405.8±35.7 °C

[ Exact Mass ]:
285.087341

[ PSA ]:
139.54000

[ LogP ]:
-0.40

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.876

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7386000
CHEMICAL NAME :
Adenosine, 2-fluoro-
CAS REGISTRY NUMBER :
146-78-1
BEILSTEIN REFERENCE NO. :
0043956
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H12-F-N5-O4
MOLECULAR WEIGHT :
285.27
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ GF D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27040 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD10 - Lethal Dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 7,69,1970

Safety Information

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26

[ WGK Germany ]:
3

[ RTECS ]:
AU7386000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Fluoro-9-β-D-(2',3',5'-tri-O-acetyl arabinofuranosyl)-adenine
  • 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine
  • 1-β-D-Arabinofuranosyluracil
  • TCMDC-124283
  • Fludarabine phosphate

DownStream

  • Fludarabine phosphate
  • TCMDC-124283
  • ribofuranose-1-phosphate
  • α-D-ribofuranosyl phosphate, free acid
  • 2-Hydrazinyl-adenosine
  • Adenosine,2'-deoxy-2-fluoro-

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2'-deoxy2-fluoroadenosine
  • 3'-Deoxy-2-fluoroadenosine
  • 5'-Deoxy-2-fluoroadenosine
  • 2',3',5'-Tri-O-acetyl-2-fluoroadenosine
  • 2-Fluoroadenosine 5'-(dihydrogen phosphate)
  • 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-deoxy-2-fluoroadenosine
  • Benzyl 4-cyano-3,3-dimethylpiperidine-1-carboxylate
  • Tert-butyl 4-(aminomethyl)-4-fluoro-3-isopropyl-piperidine-1-carboxylate
  • Methyl 2-[(7z)-1,4-dioxaspiro[4.5]decan-7-ylidene]acetate
  • (2R)-2-({2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropyl}formamido)propanoic acid
  • (2S)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-4-(methylsulfanyl)butanoic acid
  • N-[3-(propan-2-yl)-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-4-amine
  • (1RS,2SR)-2-{[(4S)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5,5,5-trifluoropentanamido]methyl}cyclopropane-1-carboxylic acid
  • 1-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]acetyl}-4,4-difluoropiperidine-3-carboxylic acid
  • 2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolan-2-yl]formamido}-4,4-difluorobutanoic acid
  • 2-{1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylbutanoyl]azetidin-3-yl}acetic acid
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