SR 48692

Suppliers

Names

[ CAS No. ]:
146362-70-1

[ Name ]:
SR 48692

[Synonym ]:
Reminertant
merclinertant
SR48692
2-({[1-(7-Chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)adamantane-2-carboxylic acid
UNII-5JBP4SI96H
2-({[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)-2-adamantanecarboxylic acid
Meclinertant
Tricyclo[3.3.1.1]decane-2-carboxylic acid, 2-[[[1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
781.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H31ClN4O5

[ Molecular Weight ]:
587.065

[ Flash Point ]:
426.2±32.9 °C

[ Exact Mass ]:
586.198303

[ PSA ]:
119.06000

[ LogP ]:
4.55

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.729

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ RTECS ]:
YD1988500

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2',6'-Dimethoxyacetophenone
  • 2-Amino-2-adamantanecarboxylic acid
  • 1-(2-Hydroxy-6-methoxyphenyl)ethanone
  • adamantanone
  • 2-benzamidoadamantane-2-carboxylic acid

DownStream

Articles

Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.

J. Pharmacol. Exp. Ther. 325(2) , 556-66, (2008)

Cocaine-primed reinstatement is an animal model of drug relapse. The neurocircuitry underlying cocaine-primed reinstatement includes a decrease in GABA in the ventral pallidum (VP) that is inhibited b...

Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.

J. Neurosci. 33(18) , 7618-26, (2013)

The lateral hypothalamus (LH) sends a dense glutamatergic and peptidergic projection to dopamine neurons in the ventral tegmental area (VTA), a cell group known to promote reinforcement and aspects of...

The role of neurotensin in positive reinforcement in the rat central nucleus of amygdala.

Behav. Brain Res. 208(2) , 430-5, (2010)

In the central nervous system neurotensin (NT) acts as a neurotransmitter and neuromodulator. It was shown that NT has positive reinforcing effects after its direct microinjection into the ventral teg...


More Articles

Related Compounds

  • SR 16832
  • SR 3677 dihydrochloride
  • SR-1277
  • SR 0987
  • SR 11302
  • SR-14150
  • 4-ethyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]piperidine-4-carboxylic acid
  • 2-ethyl-1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxolane-3-carbonyl]pyrrolidine-2-carboxylic acid
  • 3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-(thiophen-2-yl)acetamido]cyclopentane-1-carboxylic acid
  • 1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1-methylcyclopentanecarbonyl]piperidine-2-carboxylic acid
  • 2-{1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1-methylcyclopentyl]-N-(2-methoxyethyl)formamido}acetic acid
  • 2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid
  • 4-[(2-bromo-3-methylphenyl)carbamoyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
  • (2R)-1-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoyl]piperidine-2-carboxylic acid
  • 2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]formamido}-2-methylpropanoic acid
  • 3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]-3-methylbutanoic acid
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