SR 48692

Suppliers

Names

[ Name ]:
SR 48692

[Synonym ]:
Reminertant
merclinertant
SR48692
2-({[1-(7-Chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)adamantane-2-carboxylic acid
UNII-5JBP4SI96H
2-({[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)-2-adamantanecarboxylic acid
Meclinertant
Tricyclo[3.3.1.1]decane-2-carboxylic acid, 2-[[[1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
781.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₃₁ClN₄O₅

[ Molecular Weight ]:
587.065

[ Flash Point ]:
426.2±32.9 °C

[ Exact Mass ]:
586.198303

[ PSA ]:
119.06000

[ LogP ]:
4.55

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.729

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ RTECS ]:
YD1988500

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2',6'-Dimethoxyacetophenone
2-Amino-2-adamantanecarboxylic acid
1-(2-Hydroxy-6-methoxyphenyl)ethanone
adamantanone
2-benzamidoadamantane-2-carboxylic acid

DownStream

Articles

Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.

J. Pharmacol. Exp. Ther. 325(2) , 556-66, (2008)

Cocaine-primed reinstatement is an animal model of drug relapse. The neurocircuitry underlying cocaine-primed reinstatement includes a decrease in GABA in the ventral pallidum (VP) that is inhibited b...

Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.

J. Neurosci. 33(18) , 7618-26, (2013)

The lateral hypothalamus (LH) sends a dense glutamatergic and peptidergic projection to dopamine neurons in the ventral tegmental area (VTA), a cell group known to promote reinforcement and aspects of...

The role of neurotensin in positive reinforcement in the rat central nucleus of amygdala.

Behav. Brain Res. 208(2) , 430-5, (2010)

In the central nervous system neurotensin (NT) acts as a neurotransmitter and neuromodulator. It was shown that NT has positive reinforcing effects after its direct microinjection into the ventral teg...

SR 16832
SR 3677 dihydrochloride
SR-1277
SR 0987
SR 11302
SR-14150
methyl 2-((7-phenyl-6,7-dihydro-5H-imidazo[2,1-c][1,2,4]triazol-3-yl)thio)acetate
Methyl 3-[({[2-(4-chlorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]thio}acetyl)amino]thiophene-2-carboxylate
Dimethyl 2-(1-((3-chlorobenzyl)oxy)-2-oxo-1,2-dihydropyridine-3-carboxamido)terephthalate
1,4-Dimethyl 2-{1-[(3-nitrophenyl)methoxy]-2-oxo-1,2-dihydropyridine-3-amido}benzene-1,4-dicarboxylate
methyl 4-({[1-({[(4-chlorophenyl)methyl]carbamoyl}methyl)-5-(hydroxymethyl)-1H-imidazol-2-yl]sulfanyl}methyl)benzoate
(E)-methyl 4-((2-cyano-2-(4-cyclopropylthiazol-2-yl)vinyl)amino)benzoate
methyl 4-{[(1E)-2-[4-(6-chloro-2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]-2-cyanoeth-1-en-1-yl]amino}benzoate
(E)-methyl 4-((2-cyano-2-(4-(6-nitro-2-oxo-2H-chromen-3-yl)thiazol-2-yl)vinyl)amino)benzoate
(E)-methyl 4-((2-(4-(4-bromophenyl)thiazol-2-yl)-2-cyanovinyl)amino)benzoate
(E)-methyl 4-((2-cyano-2-(4-(4-fluorophenyl)thiazol-2-yl)vinyl)amino)benzoate

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