FR901464

Suppliers

Names

[ CAS No. ]:
146478-72-0

[ Name ]:
FR901464

[Synonym ]:
WB 2663B
[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
[(E,2S)-5-[[(2R,5S,6S)-6-[(2E,4E)-5-[(5S,7R,8R)-5,8-dihydroxy-5-methyl-2,6-dioxaspiro[2.5]octan-7-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
702.7ºC at 760mmHg

[ Molecular Formula ]:
C27H41NO8

[ Molecular Weight ]:
507.61600

[ Flash Point ]:
378.8ºC

[ Exact Mass ]:
507.28300

[ PSA ]:
130.34000

[ LogP ]:
3.15270

[ Vapour Pressure ]:
7.94E-23mmHg at 25°C

[ Index of Refraction ]:
1.553

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZC0702750
CHEMICAL NAME :
WB 2663B
CAS REGISTRY NUMBER :
146478-72-0
LAST UPDATED :
199806
DATA ITEMS CITED :
1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 49,1196,1996

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Spliceostatin A
  • (3R,4R,5R,7S)-7-methyl-5-vinyl-1,6-dioxaspiro[2.5]octane-4,7-diol
  • (S)-4-formylbut-3-yn-2-yl acetate
  • tert-butyl ((3R,4R)-4-hydroxypent-1-en-3-yl)carbamate
  • (E)-(2S)-6-phenylhex-5-en-3-yn-2-yl acetate

DownStream

Related Compounds

  • Methyl 4-amino-3-ethynyl-5-methoxy-2-methylbenzoate
  • tert-Butyl 4-acetyl-3-bromo-1H-indole-1-carboxylate
  • 1-methyl-3-(2-methylpropoxy)-1H-pyrazol-4-amine
  • 9-[1,1'-Biphenyl]-4-yl-9'-phenyl-2,2'-bi-9h-carbazole
  • 6-Bromo-5-chloro-2,3-dihydro-1H-inden-1-amine
  • Methyl 4-amino-2-chloro-3-ethynyl-5-propylbenzoate
  • 3-Amino-1-pyridin-3-ylmethyl-1H-pyrazole-4-carbonitrile
  • 4-Ethynyl-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid
  • Methyl 4-chloro-1H-indole-5-carboxylate
  • 5-bromo-2-methoxy-N-propan-2-ylpyridine-3-carboxamide
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