WR-1065

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Names

[ CAS No. ]:
14653-77-1

[ Name ]:
WR-1065

[Synonym ]:
Ethanethiol, 2-[(3-aminopropyl)amino]-, hydrochloride (1:1)
2-(3-aminopropylamino)ethanethiol,dihydrochloride
2-[(3-Aminopropyl)amino]ethanethiol hydrochloride (1:1)
2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride WR-1065 dihydrochloride
WR-1065 dihydrochloride

Chemical & Physical Properties

[ Density]:
0.975g/cm3

[ Boiling Point ]:
218.6ºC at 760 mmHg

[ Molecular Formula ]:
C5H16Cl2N2S

[ Molecular Weight ]:
207.16

[ Flash Point ]:
86ºC

[ PSA ]:
76.85000

[ LogP ]:
1.74780

[ Vapour Pressure ]:
0.124mmHg at 25°C

[ Index of Refraction ]:
1.496

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KJ0203000
CHEMICAL NAME :
Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrochloride
CAS REGISTRY NUMBER :
14653-77-1
LAST UPDATED :
199707
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H14-N2-S.2Cl-H
MOLECULAR WEIGHT :
207.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 24,48,1989

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Articles

A manganese superoxide dismutase (SOD2)-mediated adaptive response.

Radiat. Res. 179(2) , 115-24, (2013)

Very low doses of ionizing radiation, 5 to 100 mGy, can induce adaptive responses characterized by elevation in cell survival and reduction in micronuclei formation. Utilizing these end points, RKO hu...

Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53.

Oncogene 24(24) , 3964-75, (2005)

The aminothiol WR1065 exerts selective cytoprotective effects in normal cells compared to cancer cells and has clinical applications for the protection of normal cells in cancer patients undergoing ra...

Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.

Clin. Cancer Res. 16(3) , 1049-57, (2010)

We evaluated the pharmacokinetics of amifostine and WR1065 in pediatric patients with newly diagnosed medulloblastoma to assess the influence of patient covariates, including demographics, clinical ch...


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