Acetylsalicylic anhydride

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Names

[ CAS No. ]:
1466-82-6

[ Name ]:
Acetylsalicylic anhydride

[Synonym ]:
2-Acetoxybenzoic anhydride
Salicylic anhydride,diacetate
Acetylsalicylic acid anhydride
O-acetylsalicylic anhydride
Benzoic acid, 2- (acetyloxy)-, anhydride
Aspirin anhydride
2-acetoxy-benzoic acid-anhydride
SALICYLIC ANHYDRIDE DIACETATE
Benzoic acid, 2-(acetyloxy)-, anhydride (9CI)
Contraflu
Vigal
2-Acetoxy-benzoesaeure-anhydrid
Pircan
anhydride de l'acide acetylsalicylique
Acetylsalicylic anhydride

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
511.2±35.0 °C at 760 mmHg

[ Melting Point ]:
80-83ºC

[ Molecular Formula ]:
C18H14O7

[ Molecular Weight ]:
342.300

[ Flash Point ]:
226.4±26.0 °C

[ Exact Mass ]:
342.073944

[ PSA ]:
95.97000

[ LogP ]:
1.33

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.568

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VO0710000
CHEMICAL NAME :
Salicylic acid, acetate, anhydride
CAS REGISTRY NUMBER :
1466-82-6
BEILSTEIN REFERENCE NO. :
2015320
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H14-O7
MOLECULAR WEIGHT :
342.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Cardiac - other changes

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
300 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Aspirin
  • Benzoyl chloride
  • Acetylsalicyloyl chloride
  • (2-acetoxy-benzoyl)-carbonic acid ethyl ester
  • Pyridine
  • (2-acetoxy-benzoic acid )-acetic acid-anhydride

DownStream

  • acetylsalicylsalicylic acid
  • acetic acid
  • Salsalate
  • Ethanoic anhydride

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • Acetylsalicylic acid methyl ester
  • acetylsalicylic acid, [carboxyl-14c]
  • Methacrylic anhydride
  • Perfluorooctanoic anhydride
  • acetic anhydride carbanion
  • methanesulfinic anhydride
  • 2-Amino-1-(4-methylfuran-3-yl)ethan-1-one
  • 1-(2-Fluoroethyl)-4-(4-piperidinyl)piperazine trihydrochloride
  • (2-(3,4-dichlorophenyl)thiazolidin-3-yl)(1,3,5-trimethyl-1H-pyrazol-4-yl)methanone
  • [1-(Pyrimidin-5-yl)cyclobutyl]methanamine
  • 2-(4-methoxyphenyl)-N-(thiophen-2-ylmethyl)thiazolidine-3-carboxamide
  • 1-(2-(3-Bromo-4-methoxyphenyl)thiazolidin-3-yl)-2-(2-methoxyphenoxy)ethanone
  • 1-Ethyl-N-methylpyrrolidin-3-amine;dihydrochloride
  • (2-(2-Fluorophenyl)thiazolidin-3-yl)(4-propyl-1,2,3-thiadiazol-5-yl)methanone
  • 2-(2-Fluorophenyl)-3-(thiophen-2-ylsulfonyl)thiazolidine
  • 2-(2-fluorophenyl)-N-(thiophen-2-ylmethyl)thiazolidine-3-carboxamide
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