Acetylsalicylic anhydride

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Names

[ Name ]:
Acetylsalicylic anhydride

[Synonym ]:
2-Acetoxybenzoic anhydride
Salicylic anhydride,diacetate
Acetylsalicylic acid anhydride
O-acetylsalicylic anhydride
Benzoic acid, 2- (acetyloxy)-, anhydride
Aspirin anhydride
2-acetoxy-benzoic acid-anhydride
SALICYLIC ANHYDRIDE DIACETATE
Benzoic acid, 2-(acetyloxy)-, anhydride (9CI)
Contraflu
Vigal
2-Acetoxy-benzoesaeure-anhydrid
Pircan
anhydride de l'acide acetylsalicylique
Acetylsalicylic anhydride

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
511.2±35.0 °C at 760 mmHg

[ Melting Point ]:
80-83ºC

[ Molecular Formula ]:
C₁₈H₁₄O₇

[ Molecular Weight ]:
342.300

[ Flash Point ]:
226.4±26.0 °C

[ Exact Mass ]:
342.073944

[ PSA ]:
95.97000

[ LogP ]:
1.33

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.568

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO0710000

CHEMICAL NAME :: Salicylic acid, acetate, anhydride

CAS REGISTRY NUMBER :: 1466-82-6

BEILSTEIN REFERENCE NO. :: 2015320

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H14-O7

MOLECULAR WEIGHT :: 342.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Cardiac - other changes

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 300 mg/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%