4-(aziridin-1-yl)-6-chloropyrimidine

Names

[ Name ]:
4-(aziridin-1-yl)-6-chloropyrimidine

[Synonym ]:
Pyrimidine,4-(1-aziridinyl)-6-chloro
4-Ethyleneimino-6-chloropyrimidine
4-(1-Aziridinyl)-6-chloropyrimidine
4-aziridin-1-yl-6-chloro-pyrimidine

Chemical & Physical Properties

[ Density]:
1.455g/cm3

[ Boiling Point ]:
303.4ºC at 760mmHg

[ Molecular Formula ]:
C₆H₆ClN₃

[ Molecular Weight ]:
155.58500

[ Flash Point ]:
137.3ºC

[ Exact Mass ]:
155.02500

[ PSA ]:
28.79000

[ LogP ]:
1.01500

[ Vapour Pressure ]:
0.000933mmHg at 25°C

[ Index of Refraction ]:
1.635

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV6803000

CHEMICAL NAME :: Pyrimidine, 4-(1-aziridinyl)-6-chloro-

CAS REGISTRY NUMBER :: 14673-04-2

BEILSTEIN REFERENCE NO. :: 0908490

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H6-Cl-N3

MOLECULAR WEIGHT :: 155.60

WISWESSER LINE NOTATION :: T6N CNJ DG F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 5,101,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 5,101,1970

Related Compounds

4-(aziridin-1-yl)-6-methyl-5-nitropyrimidin-2-amine
4-(aziridin-1-yl)-6-chloro-N-(4-chlorophenyl)pyrimidin-2-amine
4-aziridin-1-yl-6-chloro-2-methylsulfanyl-pyrimidine
4-(aziridin-1-yl)-6-phenylpyrimidin-2-amine
4-(aziridin-1-yl)-6-chloro-2-(4-methoxyphenyl)pyrimidine
4-(aziridin-1-yl)-6-chloro-2-naphthalen-2-ylpyrimidine
N-(3-methylbutan-2-yl)oxolane-2-carboxamide
(5Z)-5-({3-[4-(Allyloxy)-2-methylphenyl]-1-phenyl-1H-pyrazol-4-YL}methylene)-3-(4-methylbenzyl)-2-thioxo-1,3-thiazolidin-4-one
(5Z)-5-[(1,3-Diphenyl-1H-pyrazol-4-YL)methylene]-3-dodecyl-2-thioxo-1,3-thiazolidin-4-one
(5Z)-5-{[3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-YL]methylene}-3-(2-methoxyethyl)-2-thioxo-1,3-thiazolidin-4-one
(5Z)-5-{[3-(3-chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-3-(3-ethoxypropyl)-2-thioxo-1,3-thiazolidin-4-one
(5Z)-5-{[3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-YL]methylene}-3-isobutyl-2-thioxo-1,3-thiazolidin-4-one
(5Z)-5-{[3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-YL]methylene}-3-pentyl-2-thioxo-1,3-thiazolidin-4-one
ethyl 2-{3-[(3-fluoro-4-methylphenyl)carbonyl]-2-(2-fluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}-4-methyl-1,3-thiazole-5-carboxylate
2-Methoxyethyl 2-(3-bromobenzylidene)-7-methyl-3-oxo-5-(thiophen-2-yl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
Benzyl 2-(3,4-dimethoxybenzylidene)-7-methyl-3-oxo-5-(thiophen-2-yl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

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