PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER )

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Names

[ Name ]:
PEMETREXED DIETHYL ESTER (L-GLUTAMIC ACID, N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-, 1,5-DIETHYL ESTER )

[Synonym ]:
(s)-diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate
n-[4-[2-(2-amino-4,7-dihydro-4-oxo-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]- l-glutamic acid diethyl ester
l-glutamic acid,n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-,1,5-diethyl ester

Chemical & Physical Properties

[ Density]:
1.38

[ Melting Point ]:
84-86 °C

[ Molecular Formula ]:
C₂₄H₂₉N₅O₆

[ Molecular Weight ]:
483.51700

[ Exact Mass ]:
483.21200

[ PSA ]:
169.26000

[ LogP ]:
2.59550

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

H-Glu(OEt)-OEt.HCl
4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid
diethyl N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7-(3',4'-dimethoxybenzyl)pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate
2-Chloro-4,6-dimethoxy-1,3,5-triazine
2-amino-4-oxo-5-vinyl-7-(3',4'-dimethoxybenzyl)-3,4,5,6-tetrahydropyrrolo[2,3-d]pyrimidine
methyl N-crotyl-N-(3',4'-dimethoxybenzyl)malonylamide
2-Methyl-2-propanyl 4-formylbenzoate
methyl 3-[4-(tert-butoxycarbonyl)phenyl]propenoate
methyl N-crotyl-N-(3',4'-dimethoxybenzyl)malonamide
3-(4-Carboethoxy)phenyl propanal