Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

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Names

[ CAS No. ]:
147118-35-2

[ Name ]:
Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

[Synonym ]:
(R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxo]-5-oxo-6-(triphenylphosphoranylidene)-methyl hexanoate
methyl-(3R)-3-[(terbutyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanoate
methyl (3R)-3[[tert-butyl-(dimethyl)silyl]oxy]-5-oxo-6-(triphenylphosphoranylidine)hexanoate
3-(tert-butyldimethylsilanyloxy)-5-oxo-6-(triphenylphosphanylidene)hexanoic acid methyl ester
(3R)-3-(tert-butyldiMethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate Methyl ester
METHYL (3R)-3-(TERT-BUTYLDIMETHYL SILYLOXY)-5-OXO-6-TRIPHENYL PHOSPHORANYLIDENE HEXANOATE (J6)
Methyl (3R)-3-{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-5-oxo-6-(triphenylphosphoranylidene)hexanoate
rosuvastatin interMediates J-6
B-8
Hexanoic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-6-(triphenylphosphoranylidene)-, methyl ester, (3R)-
methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
603.9±65.0 °C at 760 mmHg

[ Melting Point ]:
77.5-78.5ºC

[ Molecular Formula ]:
C31H39O4PSi

[ Molecular Weight ]:
534.698

[ Flash Point ]:
319.0±34.3 °C

[ Exact Mass ]:
534.235535

[ PSA ]:
62.41000

[ LogP ]:
6.78

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.553

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-methyl 3-((tert-butyldimethylsilyl)oxy)-6-chloro-5-oxohexanoate
  • Triphenylphosphine
  • methyl triphenylphosphonium bromide
  • (3R)-3-(tert-Butyldimethylsilyl)oxypentanedioate-1-methyl monoester
  • (R)-3-((tert-butyldimethylsilyl)oxy)-5-methoxy-5-oxopentanoic (ethyl carbonic) anhydride
  • Methyltriphenylphosphonium bromide
  • Ethyl chloroformate
  • 3-(tert-butyldimethylsilyloxy)glutaric anhydride

DownStream

  • Rosuvastatin
  • Rosuvastatin methyl ester
  • 5-Oxorosuvastatin Methyl Ester
  • 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester

Related Compounds

  • 6,7-Difluoro-1,2-dihydroquinolin-2-one
  • 4-[2-[[4-(Octahydro-1,3-dioxo-2H-isoindol-2-yl)benzoyl]oxy]acetyl]phenyl 2-furancarboxylate
  • 4-[2-[[3-(Octahydro-1,3-dioxo-2H-isoindol-2-yl)benzoyl]oxy]acetyl]phenyl 3,4-dichlorobenzoate
  • 2-(2,5-Dioxo-3',4'-dihydro-2'H-spiro[imidazolidine-4,1'-naphthalen]-1-yl)acetonitrile
  • [2-(1H-indol-3-yl)-2-oxo-1-phenylethyl] pyrazine-2-carboxylate
  • Methyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate
  • N-methyl-N-phenyl-2-((5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)thio)acetamide
  • 2-(2,4-dibromophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
  • 3-[(2-methoxyethyl)carbamoyl]-1-methyl-1H-pyrazole-4-carboxylic acid
  • 4-[(3-Methoxyphenyl)methylamino]phenol
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