Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

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Names

[ CAS No. ]:
147118-35-2

[ Name ]:
Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

[Synonym ]:
(R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxo]-5-oxo-6-(triphenylphosphoranylidene)-methyl hexanoate
methyl-(3R)-3-[(terbutyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanoate
methyl (3R)-3[[tert-butyl-(dimethyl)silyl]oxy]-5-oxo-6-(triphenylphosphoranylidine)hexanoate
3-(tert-butyldimethylsilanyloxy)-5-oxo-6-(triphenylphosphanylidene)hexanoic acid methyl ester
(3R)-3-(tert-butyldiMethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate Methyl ester
METHYL (3R)-3-(TERT-BUTYLDIMETHYL SILYLOXY)-5-OXO-6-TRIPHENYL PHOSPHORANYLIDENE HEXANOATE (J6)
Methyl (3R)-3-{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-5-oxo-6-(triphenylphosphoranylidene)hexanoate
rosuvastatin interMediates J-6
B-8
Hexanoic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-6-(triphenylphosphoranylidene)-, methyl ester, (3R)-
methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
603.9±65.0 °C at 760 mmHg

[ Melting Point ]:
77.5-78.5ºC

[ Molecular Formula ]:
C31H39O4PSi

[ Molecular Weight ]:
534.698

[ Flash Point ]:
319.0±34.3 °C

[ Exact Mass ]:
534.235535

[ PSA ]:
62.41000

[ LogP ]:
6.78

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.553

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-methyl 3-((tert-butyldimethylsilyl)oxy)-6-chloro-5-oxohexanoate
  • Triphenylphosphine
  • methyl triphenylphosphonium bromide
  • (3R)-3-(tert-Butyldimethylsilyl)oxypentanedioate-1-methyl monoester
  • (R)-3-((tert-butyldimethylsilyl)oxy)-5-methoxy-5-oxopentanoic (ethyl carbonic) anhydride
  • Methyltriphenylphosphonium bromide
  • Ethyl chloroformate
  • 3-(tert-butyldimethylsilyloxy)glutaric anhydride

DownStream

  • Rosuvastatin
  • Rosuvastatin methyl ester
  • 5-Oxorosuvastatin Methyl Ester
  • 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester

Related Compounds

  • (2S)-2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]hexanoic acid
  • 2-{1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]cyclopentyl}acetic acid
  • 5-{[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]methyl}furan-2-carboxylic acid
  • 2-[3-(benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-4-chlorobenzoic acid
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-oxo-4-(3-oxo-1,4-diazepan-1-yl)butanoic acid
  • 1-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methoxybutanamido]methyl}cyclobutane-1-carboxylic acid
  • 2-Fluoro-4-methoxy-3-(methoxymethoxy)benzoic acid
  • 4-[3-cyclopropyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-3-methylbutanoic acid
  • 3-(2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]sulfanyl}acetamido)propanoic acid
  • 2-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(2-hydroxyethyl)-4-methylpentanamido]acetic acid
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