5-Oxorosuvastatin Methyl Ester

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Names

[ CAS No. ]:
147118-39-6

[ Name ]:
5-Oxorosuvastatin Methyl Ester

[Synonym ]:
Methyl 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL]-(3R,5R)-DIHYDROXY-(E)-6-HEPTENATE
(R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)-3-hydroxy-5-oxohept-6-enoate
methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate
Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
Methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-5-oxohept-6-enoate
methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptanate
Methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3-hydroxy-5-oxo-6-heptenoate
methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate
methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate
methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenoate
Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methanesul fonylaMino) pyriMidin-5-y
7-[4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl-methyl-amino)pyrimidin-5-yl]-3-hydroxy-5-oxo-hept-6-enoic acid methyl ester
5-Oxorosuvastatin methyl ester
6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, (3R,6E)-
ZD-6
(3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester
Methyl (+)-(3R)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-(N-Methyl-NMethansulphonylaMino) pyriMidin-5-yl]-3-hydroxy-5-oxo- 6(E)-heptenoate
methyl (3R,6E)-7-[4-(4-flurophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)mino]-5-pyrimidyl]-3-hydroxy-5-oxo-6-heptenoate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
701.7±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H28FN3O6S

[ Molecular Weight ]:
493.548

[ Flash Point ]:
378.2±35.7 °C

[ Exact Mass ]:
493.168274

[ PSA ]:
135.14000

[ LogP ]:
1.40

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
  • Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
  • N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
  • 3-(tert-butyldimethylsilyloxy)glutaric anhydride
  • 4-Fluorobenzaldehyde
  • Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-methylthiopyrimidine-5-carboxylate
  • 4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino]pyriminl-5-yl-methanol
  • ethyl 4-(4-fluorophenyl)-2-methylsulfonyl-6-propan-2-ylpyrimidine-5-carboxylate

DownStream

  • Rosuvastatin
  • Rosuvastatin methyl ester

Related Compounds

  • 4-[(Phenylamino)methylene]-2-pentenedioic Acid 5-Methyl Ester
  • erythro-Pentaric acid, 3-deoxy-, 1,4-lactone, 5-methyl ester (9CI)
  • D-threo-Pentaric acid, 3-deoxy-, 1,4-lactone, 5-methyl ester (9CI)
  • Boc-glu(ome)-oh dcha
  • Pentanedioic acid, 2-cyano-2-fluoro-4-methyl-, 1-ethyl 5-methyl ester (9CI)
  • D-threo-Penturonic acid, 2-(acetylamino)-2,3-dideoxy-, gamma-lactone, 5-methyl ester (9CI)
  • Tert-butyl 3-(2-fluoroethoxy)pyrrolidine-1-carboxylate
  • 3-Bromo-6-(phenylmethoxy)pyridazine
  • 1H-Pyrazole, 5-(chloromethyl)-1-[(4-methoxyphenyl)methyl]-
  • 1,1-Dimethylethyl 3-(fluoromethyl)-4-(phenylmethyl)-1-piperazinecarboxylate
  • 3-(Hydrazinylmethyl)benzoic acid
  • N-[4-(4-Methoxyphenyl)oxan-4-yl]prop-2-enamide
  • 2-(((2-Fluoro-5-(trifluoromethyl)phenyl)amino)ethylidene)indane-1,3-dione
  • 2-{1-[(4-Methoxyphenyl)amino]ethylidene}cyclohexane-1,3-dione
  • 2-(((6-Methoxy-3-pyridyl)amino)methylene)indane-1,3-dione
  • methyl (2Z)-[2-[(2-methoxyphenyl)amino]-4-oxo-1,3-thiazol-5(4H)-ylidene]acetate
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