N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline

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Names

[ CAS No. ]:
147266-92-0

[ Name ]:
N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline

[Synonym ]:
(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline
Boc-trans-4-Hydroxy-D-proline
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R,4S)-
N-Boc-trans-4-hydroxy-D-proline
MFCD01861341

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
390.9±42.0 °C at 760 mmHg

[ Melting Point ]:
123ºC

[ Molecular Formula ]:
C10H17NO5

[ Molecular Weight ]:
231.246

[ Flash Point ]:
190.2±27.9 °C

[ Exact Mass ]:
231.110672

[ PSA ]:
87.07000

[ LogP ]:
-0.71

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.531

[ Storage condition ]:
2-8°C

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

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Precursor & DownStream

Precursor

  • Di-tert-butyl dicarbonate
  • L-Hydroxyproline
  • L-Hydroxyproline
  • (2R)-N-Boc-trans-4-acetoxy-D-proline ethyl ester
  • (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester
  • (2R)-2-amino-3-(2-oxiranyl)propionic acid

DownStream

  • (2R,4S)-tert-Butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-(tert-butoxycarbonyl)-trans-4-hydroxy-D-proline ethyl ester
  • N-(tert-butoxycarbonyl)-trans-4-formyloxy-D-proline ethyl ester
  • N-(tert-butoxycarbonyl)-trans-4-acetoxy-D-proline methyl ester
  • N-(tert-Butoxycarbonyl)-allo-4-hydroxy-D-proline Ethyl Ester p-Toluenesulfonate
  • N-(tert-Butoxycarbonyl)-4-hydroxy-D-prolinol Di-p-toluenesulfonate
  • N-tert-butoxycarbonyl-trans-4-(trifluoromethylsulfonyloxy)-L-proline methyl ester