2-Methoxycinnamic acid

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Names

[ CAS No. ]:
14737-91-8

[ Name ]:
2-Methoxycinnamic acid

[Synonym ]:
trans-ortho-methoxy-cinnamic acid
2-Propenoic acid, 3-(2-methoxyphenyl)-, (2Z)-
(2E)-3-(2-Methoxyphenyl)acrylic acid
MFCD00004375
2-Methoxycinnamic acid
(2Z)-3-(2-Methoxyphenyl)acrylic acid
cis-2-MethoxycinnaMic Acid
o-methoxy cinnamic acid
(Z)-3-(2-methoxyphenyl)prop-2-enoic acid
2-Propenoic acid, 3-(2-methoxyphenyl)-, (2E)-
cis-O-Methyl-o-cumaric Acid
EINECS 238-803-5

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
325.1±17.0 °C at 760 mmHg

[ Melting Point ]:
94-96ºC(lit.)

[ Molecular Formula ]:
C10H10O3

[ Molecular Weight ]:
178.185

[ Flash Point ]:
130.3±14.4 °C

[ Exact Mass ]:
178.062988

[ PSA ]:
46.53000

[ LogP ]:
2.42

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.591

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD9720000
CHEMICAL NAME :
Cinnamic acid, o-methoxy-, (Z)-
CAS REGISTRY NUMBER :
14737-91-8
BEILSTEIN REFERENCE NO. :
2209713
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H10-O3
MOLECULAR WEIGHT :
178.20
WISWESSER LINE NOTATION :
QV1U1R BO1 -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,443,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,443,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,443,1959

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GD9720000

[ HS Code ]:
2918990090

Synthetic Route

Precursor & DownStream

Precursor

  • cis-4-(2-Methoxyphenyl)but-3-enoic acid ethyl ester
  • Coumarin
  • methyl iodide
  • 2-Methoxycinnamic acid
  • o-Anisaldehyde
  • methyl (Z)-3-(2-methoxyphenyl)-2-propenoate
  • Dimethyl sulfate

DownStream

  • Coumarin
  • 1-acetoxy-2,2-dichloro-1-(2-methoxyphenyl)ethane
  • 1,2,2-trichloro-1-(2-methoxyphenyl)ethane
  • 3-(2-Methoxyphenyl)propanoic acid
  • 2-Methoxycinnamic acid
  • (E)-Ethyl 3-(2-methoxyphenyl)acrylate
  • 3-(2-methoxyphenyl)prop-2-enamide
  • Salicylic acid
  • FEMA 3181

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • 2-Methoxycinnamic acid
  • 2-Methoxycinnamic acid
  • TRANS-2-METHOXYCINNAMIC ACID
  • 5-bromo-2-methoxycinnamic acid
  • 4-fluoro-2-methoxycinnamic acid
  • 5-Fluoro-2-Methoxycinnamic Acid
  • 1'-((1-methyl-1H-imidazol-4-yl)sulfonyl)-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • N-(2-(benzo[d][1,3]dioxol-5-yl)-2-hydroxypropyl)-2-(4-fluorophenyl)acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine