Azilsartan
Suppliers
Names
[ CAS No. ]:
147403-03-0
[ Name ]:
Azilsartan
[Synonym ]:
TAK 536
Azilsartan
2-Ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid
UNII-F9NUX55P23
1H-Benzimidazole-7-carboxylic acid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy
2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-
2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C25H20N4O5
[ Molecular Weight ]:
456.450
[ Exact Mass ]:
456.143372
[ PSA ]:
123.24000
[ LogP ]:
4.21
[ Appearance of Characters ]:
white to beige
[ Index of Refraction ]:
1.695
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: soluble15mg/mL (clear solution)
MSDS
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Articles
Rapid Commun. Mass Spectrom. 29 , 1437-47, (2015)
Azilsartan medoxomil potassium (AZM) is a new antihypertensive drug introduced in the year 2011. The presence of degradation products not only affects the quality, but also the safety aspects of the d...
Horm. Metab. Res. 46(6) , 379-83, (2014)
Advanced glycation end products (AGEs) and their receptor (RAGE) system are involved in diabetic nephropathy. Angiotensin-converting enzyme 2 (ACE 2) plays a protective role against cardiovascular and...
PLoS ONE 11 , e0147786, (2016)
A potent angiotensin II type-1 receptor blocker, azilsartan, has been reported to reduce blood pressure more effectively than candesartan. Interestingly, azilsartan can also restore the circadian rhyt...