10H-Phenothiazine,2-methoxy-10-[2-(1-methyl-2-piperidinyl)ethyl]-

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Names

[ CAS No. ]:
14759-04-7

[ Name ]:
10H-Phenothiazine,2-methoxy-10-[2-(1-methyl-2-piperidinyl)ethyl]-

[Synonym ]:
KS 33
Oxyridazine
Oxiridazinum

Chemical & Physical Properties

[ Density]:
1.137g/cm3

[ Boiling Point ]:
503.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₆N₂OS

[ Molecular Weight ]:
354.50900

[ Flash Point ]:
258.3ºC

[ Exact Mass ]:
354.17700

[ PSA ]:
41.01000

[ LogP ]:
5.17520

[ Vapour Pressure ]:
2.89E-10mmHg at 25°C

[ Index of Refraction ]:
1.597

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP0875000

CHEMICAL NAME :: Phenothiazine, 2-methoxy-10-(2-(1-methyl-2-piperidyl)ethyl)-

CAS REGISTRY NUMBER :: 14759-04-7

BEILSTEIN REFERENCE NO. :: 6118065

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H26-N2-O-S

MOLECULAR WEIGHT :: 354.55

WISWESSER LINE NOTATION :: T C666 BN ISJ EO1 B2- BT6NTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,27,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIGZAY Niigata Igakkai Zasshi. Niigata Medical Journal. (Niigata Igakkai, 1, Asahi-machi, Niigata 951, Japan) V.60- 1946- Volume(issue)/page/year: 82,607,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 516 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(2),104S,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(2),104S,1969

Safety Information

[ HS Code ]:
2934300000

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

2-Chloro-5-phenylamino-benzoic acid
4-Methyl-2-[(3-methylbutan-2-yl)amino]pentan-1-ol
2-Chloro-5-(methyl-(pyridin-2-yl)-amino)-benzoic acid methyl ester
Propanamide, N-[1-(hydroxymethyl)-3-methylbutyl]-3-[(1-methylethyl)amino]-
Ethyl 3,5-dibromo-4-nitrothiophene-2-carboxylate
2-Chloro-5-(methyl(6-methylsulfanylpyrimidin-4-yl)amino)benzoic acid
4-Methyl-2-[(thian-4-yl)amino]pentan-1-ol
2-Chloro-5-((1-methyl-6-oxo-1,6-dihydro-pyridin-2-yl)amino)-benzoic acid methyl ester
Methyl 4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylate
2-Chloro-5-((1-methyl-6-oxo-1,6-dihydro-pyridin-2-yl)amino)-benzoic acid

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