10H-Phenothiazine,2-methoxy-10-[2-(1-methyl-2-piperidinyl)ethyl]-

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Names

[ CAS No. ]:
14759-04-7

[ Name ]:
10H-Phenothiazine,2-methoxy-10-[2-(1-methyl-2-piperidinyl)ethyl]-

[Synonym ]:
KS 33
Oxyridazine
Oxiridazinum

Chemical & Physical Properties

[ Density]:
1.137g/cm3

[ Boiling Point ]:
503.5ºC at 760mmHg

[ Molecular Formula ]:
C21H26N2OS

[ Molecular Weight ]:
354.50900

[ Flash Point ]:
258.3ºC

[ Exact Mass ]:
354.17700

[ PSA ]:
41.01000

[ LogP ]:
5.17520

[ Vapour Pressure ]:
2.89E-10mmHg at 25°C

[ Index of Refraction ]:
1.597

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP0875000
CHEMICAL NAME :
Phenothiazine, 2-methoxy-10-(2-(1-methyl-2-piperidyl)ethyl)-
CAS REGISTRY NUMBER :
14759-04-7
BEILSTEIN REFERENCE NO. :
6118065
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H26-N2-O-S
MOLECULAR WEIGHT :
354.55
WISWESSER LINE NOTATION :
T C666 BN ISJ EO1 B2- BT6NTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,27,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIGZAY Niigata Igakkai Zasshi. Niigata Medical Journal. (Niigata Igakkai, 1, Asahi-machi, Niigata 951, Japan) V.60- 1946- Volume(issue)/page/year: 82,607,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
516 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(2),104S,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(2),104S,1969

Safety Information

[ HS Code ]:
2934300000

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 5-bromo-1-[2-(3-methylpyrrolidin-1-yl)ethyl]-1H-1,2,4-triazol-3-amine
  • 3-{[3-(ethylsulfanyl)phenyl]carbamoyl}-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • 4-[(3,5-diiodophenyl)carbamoyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
  • 2-oxo-5-(1H-1,2,3,4-tetrazol-1-yl)pentanoic acid
  • 3-(3-amino-4-methyl-1H-pyrazol-1-yl)pyrrolidin-2-one
  • 3,3a(2)-[Cyclohexylidenebis(4,1-phenylene-2,1-diazenediyl)]bis[5-(benzoylamino)-4-hydroxy-2,7-naphthalenedisulfonic acid]
  • tert-butyl N-[2-(4,5-dihydrofuran-3-yl)-2-oxoethyl]-N-ethylcarbamate
  • tert-butyl N-[3-(but-3-yn-2-yl)phenyl]carbamate
  • 7-methoxy-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine
  • Methyl [1,3]oxazolo[4,5-b]pyridine-6-carboxylate
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