1H-Indol-3-yl(oxo)acetic acid

Names

[ CAS No. ]:
1477-49-2

[ Name ]:
1H-Indol-3-yl(oxo)acetic acid

[Synonym ]:
Indole-3-glyoxylic acid
MFCD00005625
EINECS 216-029-9

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
413.0±27.0 °C at 760 mmHg

[ Melting Point ]:
217 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₇NO₃

[ Molecular Weight ]:
189.167

[ Flash Point ]:
203.6±23.7 °C

[ Exact Mass ]:
189.042587

[ PSA ]:
70.16000

[ LogP ]:
0.61

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.712

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

indole-3-glyoxylyl chloride
Methyl indolyl-3-glyoxylate
m-Cresol
Indole
Indole-3-carboxaldehyde
Oxalyl chloride
(1H-Indol-3-yl)-oxo-acetic acid ethyl ester
1-(1,2-Dioxo-2-(3-indolyl)ethyl)indole
3-Acetylindole

DownStream

Indole-3-carboxaldehyde
L(-)-Tryptophan
3-Indoleacetic acid
3-Cyanoindole
Tryptophol
D,L-3-Indolylglycine
Bisindolylmaleimide IV
Bisindolylmaleimide I (GF109203X)
Methyl indolyl-3-glyoxylate
indole-3-glyoxylyl chloride

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Lasting chemiluminescence of 3-indoleglyoxylyl chloride and its enhancement.

Anal. Sci. 19(1) , 123-7, (2003)

The chemiluminescence (CL) intensities of various indole derivatives substituted with a glyoxylyl group at the 3-position and a hydroxyl group at the 5-position of the indole ring were compared upon t...

Synthetic studies towards oxazinins. An expedient first total synthesis and proof of the absolute stereochemistry of oxazinin-3. Couladouros EA, et al.

Tetrahedron Lett. 45(41) , 7779-81, (2004)

Characterization of two new matrices for matrix-assisted laser desorption/ionization mass spectrometry.

Rapid Commun. Mass Spectrom. 10(7) , 839-44, (1996)

Three structurally related compounds, 4-hydroxy-33-methoxyphenylpyruvic acid (HMPPA), indole-3 pyruvic acid (IPA), and indole-3-glyoxylic acid have been evaluated as matrix-assisted laser desorption/i...

(1H-Indol-3-yl)-oxo-acetic acid ethyl ester
(5-fluoro-1H-indol-3-yl)-oxo-acetic acid ethyl ester
(5-METHOXY-1H-INDOL-3-YL)(OXO)ACETIC ACID
(7-Bromo-1H-indol-3-yl)-oxo-acetic acid methyl ester
1H-Indole-3-acetic acid, 6-bromo-alpha-oxo-
(6-fluoro-1H-indol-3-yl)-oxo-acetic acid ethyl ester
7-Fluoro-4-(3-{octahydrocyclopenta[c]pyrrol-2-yl}azetidin-1-yl)quinazoline
2-methyl-4-{4-[6-(4-methyl-1H-pyrazol-1-yl)pyridin-2-yl]piperazin-1-yl}-6-(trifluoromethyl)pyrimidine
1-[(6-Methoxypyridin-3-yl)methyl]-2-methyl-4-{thieno[2,3-d]pyrimidin-4-yl}piperazine
6-ethyl-2-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1,3-benzothiazole
1-Methyl-4-({4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}methyl)-1,2-dihydropyridin-2-one
3-Cyclopropyl-1-[1-(4-methoxy-1,3-benzothiazol-2-yl)piperidin-4-yl]imidazolidine-2,4-dione
5-Fluoro-2-{5-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-octahydropyrrolo[3,4-c]pyrrol-2-yl}pyridine
5-ethyl-2-{4-[6-(2-methyl-1H-imidazol-1-yl)pyridin-2-yl]piperazin-1-yl}pyrimidine
4-(4-Chlorophenyl)-1-{2-methylpyrazolo[1,5-a]pyrazin-4-yl}piperidin-4-ol
6-{4-[6-(1H-pyrazol-1-yl)pyridin-2-yl]piperazin-1-yl}pyridine-3-carbonitrile

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