2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide

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Names

[ CAS No. ]:
148-56-1

[ Name ]:
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide

[Synonym ]:
Trifluoromethylthiazide
Flumethazide
Trifluomethylthiazide
Fludemil
Ademol
Ademil
Flumetiazid
EINECS 205-717-4
6-Trifluormethyl-7-sulfamoyl-2H-benzo-1,2,4-thiadiazol-S,S-dioxid
6-trifluoromethyl-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
Flumethiazid
7-Sulfamoyl-6-trifluormethyl-1,2,4-benzothiadiazin-dioxid-(1,1)
Routrax
Flumethiazide

Chemical & Physical Properties

[ Density]:
1.99g/cm3

[ Boiling Point ]:
560ºC at 760mmHg

[ Molecular Formula ]:
C8H6F3N3O4S2

[ Molecular Weight ]:
329.27600

[ Exact Mass ]:
328.97500

[ PSA ]:
135.45000

[ LogP ]:
2.93080

[ Index of Refraction ]:
1.673

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK9800000
CHEMICAL NAME :
4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
CAS REGISTRY NUMBER :
148-56-1
LAST UPDATED :
199601
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H6-F3-N3-O4-S2
MOLECULAR WEIGHT :
329.29
WISWESSER LINE NOTATION :
T66 BSWM ENJ HXFFF ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1760 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
910 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,405,1960

Safety Information

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

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  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • (1S,4R,5S)-4-aminobicyclo[3.1.0]hexane-1-carboxylic acid;hydrochloride