Pilocarpine nitrate
Suppliers
Names
[ CAS No. ]:
148-72-1
[ Name ]:
Pilocarpine nitrate
[Synonym ]:
MFCD00078497
(3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one nitrate
Pilocarpine nitrate
EINECS 205-723-7
Chemical & Physical Properties
[ Boiling Point ]:
520.5ºC at 760 mmHg
[ Melting Point ]:
173,5-174°C
[ Molecular Formula ]:
C11H17N3O5
[ Molecular Weight ]:
271.27000
[ Flash Point ]:
268.6ºC
[ Exact Mass ]:
271.11700
[ PSA ]:
110.17000
[ LogP ]:
1.33730
[ Vapour Pressure ]:
1.16E-11mmHg at 25°C
[ Index of Refraction ]:
81 ° (C=2, H2O)
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
H2O: 0.1 g/mL, clear, very faintly yellow
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TK1455000
- CHEMICAL NAME :
- Pilocarpine, mononitrate
- CAS REGISTRY NUMBER :
- 148-72-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C11-H16-N2-O2.H-N-O3
- MOLECULAR WEIGHT :
- 271.31
- WISWESSER LINE NOTATION :
- T5OVTJ C2 D1- ET5N CNJ A1 &WNO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 911 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume decreased
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 345 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15600 mg/kg/15W-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2200 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - skin and skin appendages
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 344,103,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81934 No. of Facilities: 42 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 980 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81934 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1525 (estimated) No. of Female Employees: 1273 (estimated)
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H330
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P260-P304 + P340 + P310-P403 + P233
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S1-S25-S45
[ RIDADR ]:
3087
[ WGK Germany ]:
3
[ RTECS ]:
TK1455000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2934999090
Synthetic Route
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Nat. Chem. Biol. 3(5) , 268-273, (2007)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...
J. Neurosci. 34(29) , 9720-35, (2014)
The mechanisms of action of many CNS drugs have been studied extensively on the level of their target proteins, but the effects of these compounds on the level of complex CNS networks that are compose...
J. Biomed. Nanotechnol. 9(1) , 124-31, (2013)
With aim of improving the availability of drug at intraocular level and to reduce the frequency of drug administration, pilocarpine nitrate nanosuspensions were made from inert polymer resin (Eudragit...