4′-Fluoro-2′-hydroxyacetophenone

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Names

[ CAS No. ]:
1481-27-2

[ Name ]:
4′-Fluoro-2′-hydroxyacetophenone

[Synonym ]:
1-Acetyl-4-fluoro-2-hydroxybenzene
4′-Fluoro-2′-hydroxyacetophenone
Ethanone, 1-(4-fluoro-2-hydroxyphenyl)-
1-(4-Fluoro-2-hydroxyphenyl)ethanone
4-Fluoro-2-Hydroxyacetophenone
MFCD00143203
QR CF FV1
1-(4-Fluoro-2-hydroxyphenyl)ethan-1-one
4'-Fluoro-2'-hydroxyacetophenone

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
237.5±20.0 °C at 760 mmHg

[ Melting Point ]:
32-34°C

[ Molecular Formula ]:
C8H7FO2

[ Molecular Weight ]:
154.138

[ Flash Point ]:
97.4±21.8 °C

[ Exact Mass ]:
154.043015

[ PSA ]:
37.30000

[ LogP ]:
2.42

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.530

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2914399090

Synthetic Route

Precursor & DownStream

Precursor

  • 3-Fluorophenyl acetate
  • 4'-Fluoroacetophenone
  • 3-Fluorophenol
  • acetic acid
  • 2',4'-Difluoroacetophenone

DownStream

  • 7-Fluoro-2,2-dimethylchroMan-4-one
  • 4-Fluoro-2-methoxyphenol
  • 4'-Fluoro-2'-methoxyacetophenone
  • 7-Fluoro-4-hydroxy-2H-chromen-2-one
  • 7-Fluoro-4-oxo-4H-chromene-2-carboxylic acid
  • 3-(dimethylamino)-1-(4-fluoro-2-hydroxyphenyl)prop-2-en-1-one
  • 5-FLUORO-7-HYDROXYBENZOFURAN
  • 2(3H)-Benzoxazolone,6-fluoro-
  • 7-Fluorochromone-3-carboxaldehyde
  • 1-[4-fluoro-2-(methoxymethoxy)phenyl]ethanone

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis, characterization and biological evaluation of novel 4'-fluoro-2'-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents.

J. Enzyme Inhib. Med. Chem. , 1-8, (2014)

In an effort to develop safe and potent anti-inflammatory agents, a series of novel 4'-fluoro-2'-hydroxychalcones 5a-d and their dihydropyrazole derivatives 6a-d was prepared. It was synthesized via a...

19F NMR study on the biological Baeyer-Villiger oxidation of acetophenones.

J. Ind. Microbiol. Biotechnol. 26(1-2) , 35-42, (2001)

The biological Baeyer-Villiger oxidation of acetophenones was studied by 19F nuclear magnetic resonance (NMR). The 19F NMR method was used to characterise the time-dependent conversion of various fluo...

J. Heterocycl. Chem. 30 , 445, (1993)


More Articles


Related Compounds

  • 5′-Fluoro-2′-hydroxyacetophenone
  • 4'-Fluoro-2'-methoxyacetophenone
  • 4'-Fluoro-2'-(trifluoromethyl)acetophenone
  • 4'-fluoro-2'-nitroacetanilide
  • 4'-Fluoro-2'-methylacetophenone
  • 2'-Deoxy-2'-fluorocytidine