Ivabradine hydrochloride

Suppliers

Names

[ Name ]:
Ivabradine hydrochloride

[Synonym ]:
Ivabradine hydrochloride
AMG 998
Coralan
Procoralan
Corlentor
3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one,hydrochloride
ivabradine monohydrochloride
2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride
Ivabradine hcl
2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)
MFCD00929899
3-{3-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride (1:1)
UNII-TP19837BZK
Corlanor

Chemical & Physical Properties

[ Boiling Point ]:
626.9ºC at 760mmHg

[ Melting Point ]:
193-196?C

[ Molecular Formula ]:
C₂₇H₃₇ClN₂O₅

[ Molecular Weight ]:
505.046

[ Flash Point ]:
332.9ºC

[ Exact Mass ]:
504.239105

[ PSA ]:
60.47000

[ LogP ]:
4.04990

[ Vapour Pressure ]:
1.24E-15mmHg at 25°C

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ Hazard Codes ]:
N

[ Risk Phrases ]:
50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

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Precursor & DownStream

Precursor

3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]Methylamino]propyl]-1,3-dihydro-7,8-dimethoxy-H-3-benzazepin-2-one
Ivabradine
7,8-Dimethoxy-1,3,4,5-tetrahydrobenzo[d]azepin-2-one
3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N-methyl-1-propanamine
4,5-Dimethoxy-1-cyanobenzocyclobutane
4,5-Dimethoxybenzocyclobutene-1-carboxylic acid
3-(2-Bromo-4,5-dimethoxyphenyl)propanenitrile
(S)-(4,5-dimethoxy-1,2-dihydrocyclobutabenzen-1-yl)-N-Methylmethanamine
2H-3-Benzazepin-2-one, 3-(3-chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-

DownStream

Articles

Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs.

Cell Physiol. Biochem. 38 , 646-58, (2016)

Heart rate variability (HRV) refers to the fluctuation of the time interval between consecutive heartbeats in humans. It has recently been discovered that cardiomyocytes derived from human embryonic a...