2-BROMOACRYLALDEHYDE

Names

[ Name ]:
2-BROMOACRYLALDEHYDE

[Synonym ]:
2-Bromo-2-propenal
2-Bromoacrylaldehyde
2-Bromo-acrylaldehyde,2-Bromopropenal
bromoacrolein
2-bromoprop-2-enal
2-Bromopropenal

Chemical & Physical Properties

[ Density]:
1.617g/cm3

[ Boiling Point ]:
149.1ºC at 760mmHg

[ Molecular Formula ]:
C₃H₃BrO

[ Molecular Weight ]:
134.95900

[ Flash Point ]:
97.2ºC

[ Exact Mass ]:
133.93700

[ PSA ]:
17.07000

[ LogP ]:
1.09390

[ Vapour Pressure ]:
4.08mmHg at 25°C

[ Index of Refraction ]:
1.473

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AS1110000

CHEMICAL NAME :: Acrolein, 2-bromo-

CAS REGISTRY NUMBER :: 14925-39-4

BEILSTEIN REFERENCE NO. :: 1698247

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C3-H3-Br-O

MOLECULAR WEIGHT :: 134.97

WISWESSER LINE NOTATION :: VHYEU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 500 nmol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 6,705,1985

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H311 + H331-H314-H400

[ Precautionary Statements ]:
P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T,N

[ Risk Phrases ]:
23/24/25-34-50

[ Safety Phrases ]:
26-36/37/39-45-61

[ RIDADR ]:
UN3286 3/PG 2

[ RTECS ]:
AS1110000

[ HS Code ]:
2913000090

Precursor & DownStream

Precursor

DownStream

Pyrazole
2,2,3-Tribromopropanal
1,1,3-TRIS(PHENYLTHIO)-1-PROPENE
2-bromo-3,3-diethoxyprop-1-ene
ENANTHALDEHYDE, A-BROMO-
4-[(2-methylphenyl)methylideneamino]-5-(4-tert-butylphenyl)-2H-1,2,4-triazole-3-thione
Bicyclo[2.2.1]hept-2-ene,5-methylene-
2-bromohexa-1,5-dien-3-ol

Customs

[ HS Code ]: 2913000090

[ Summary ]:
HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%

Articles

Metabolism and genotoxicity of the halogenated alkyl compound tris(2,3-dibromopropyl)phosphate.

Hum. Exp. Toxicol. 13(12) , 861-5, (1994)

1. The genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) was studied in vivo. Results showed that Tris-BP was highly clastogenic, but it could only initiate a low number o...

Genotoxicity of 2-halosubstituted enals and 2-chloroacrylonitrile in the Ames test and the SOS-chromotest.

Mutat. Res. 322(4) , 321-8, (1994)

2-Chloroacrolein and 2-bromoacrolein are very potent direct mutagens not requiring metabolic activation in Salmonella typhimurium strains TA 100 and TA 1535. Mutagenic activities decrease with increas...

Formation of thymidine, cyclic deoxyguanosine and cyclic deoxycytidine adducts of the mutagen 2-bromoacrolein and their role in mutagenicity and clastogenicity.

IARC Sci. Publ. (125) , 449-52, (1994)

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2-methyl-2-methylsulfanylpropanenitrile
2-(4-methoxyphenyl)-4-nitrobenzoic acid
2-(4-methoxyphenyl)-5-methylbenzoic acid
2-(4-methoxyphenyl)-6-methylbenzoic acid
2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene