Arachidonyl trifluoromethyl ketone

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
421.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₁F₃O

[ Molecular Weight ]:
356.465

[ Flash Point ]:
288.7±20.2 °C

[ Exact Mass ]:
356.232697

[ PSA ]:
17.07000

[ LogP ]:
7.78

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.463

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.

J. Neuroinflammation 12 , 199, (2015)

Oxidative stress and inflammation are important factors contributing to the pathophysiology of numerous neurological disorders, including Alzheimer's disease, Parkinson's disease, acute stroke, and in...

Cytoplasmic phospholipase A₂ modulation of adolescent rat ethanol-induced protein kinase C translocation and behavior.

Neurochem. Res. 40 , 1023-31, (2015)

Ethanol consumption typically begins during adolescence, a developmental period which exhibits many age-dependent differences in ethanol behavioral sensitivity. Protein kinase C (PKC) activity is larg...

Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice.

Brain Res. 1471 , 129-37, (2012)

It is postulated that inhibition of cytosolic phospholipase A(2) alpha (cPLA(2)α) can reduce severity of stroke injury. This is supported by the finding that cPLA(2)α-deficient mice are partially prot...

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