AHU 377

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Names

[ CAS No. ]:
149709-62-6

[ Name ]:
AHU 377

[Synonym ]:
4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid
AHU-377
ENTRESTO
4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid
UNII-17ERJ0MKGI
AHU377
Sacubitril
[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αR,γS)-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
656.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H29NO5

[ Molecular Weight ]:
411.491

[ Flash Point ]:
351.1±31.5 °C

[ Exact Mass ]:
411.204559

[ PSA ]:
96.19000

[ LogP ]:
3.96

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.549

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Sacubitril sodium
  • Boc-L-phe(4-ph)-OH
  • Boc-D-Tyr-OMe
  • methyl (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoate

DownStream

Related Compounds

  • AHU-377 hemicalcium salt
  • Sacubitril sodium
  • MS-377
  • BIRT 377
  • TGP-377/421
  • (propan-2-ylideneamino) N-[[1,4-dimethyl-3-[[(propan-2-ylideneamino)oxycarbonylamino]methyl]cyclohexyl]methyl]carbamate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • Methyl 2-amino-2-(5-{[(tert-butoxy)carbonyl]amino}-2-fluorophenyl)acetate
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 1-(3-Hydroxyazetidin-3-yl)-4,4-dimethylcyclohexane-1-carboxylic acid