Spiro[2H-1-benzopyran-2,2'-[2H]indole],1',3'-dihydro-1',3',3'-trimethyl-6-nitro-

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Names

[ Name ]:
Spiro[2H-1-benzopyran-2,2'-[2H]indole],1',3'-dihydro-1',3',3'-trimethyl-6-nitro-

[Synonym ]:
EINECS 216-102-5
1',3',3'-Trimethyl-6-nitrospiro[1(2H)-benzopyran-2,2'-indoline]
1,3,3-Trimethylindolino-6'-nitrobenzopyrylospiran [Photochromic Compound]
MFCD00059175
1',3',3'-trimethyl-6-nitrospiro[chromene-2,2'-indole]

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
476.3ºC at 760mmHg

[ Melting Point ]:
32ºC

[ Molecular Formula ]:
C₁₉H₁₈N₂O₃

[ Molecular Weight ]:
322.35800

[ Flash Point ]:
241.9ºC

[ Exact Mass ]:
322.13200

[ PSA ]:
58.29000

[ LogP ]:
4.71250

[ Vapour Pressure ]:
3.08E-09mmHg at 25°C

[ Index of Refraction ]:
1.67

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG9870000

CHEMICAL NAME :: Spiro(2H-1-benzopyran-2,2'-indoline), 6-nitro-1',3',3'-trimethyl-

CAS REGISTRY NUMBER :: 1498-88-0

BEILSTEIN REFERENCE NO. :: 0040498

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H18-N2-O3

MOLECULAR WEIGHT :: 322.39

WISWESSER LINE NOTATION :: T66 BOXJ HNW C-& CT56 BNX DHJ B1 D1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07770

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
WG9870000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,3,3 TRIMETHYL-2-METHYLENE INDOLINE
5-Nitrosalicylaldehyde
1,2,3,3-Tetramethyl-3H-indolium iodide
1,3,3-trimethyl-2-(3-methyl-2-buten-1-ylidene)indoline
1,3,3-trimethyl-2-(3-phenylprop-2-enylidene)indoline
2,3,3-Trimethylindolenine
1,3,3-trimethyl-2-(2-penten-1-ylidene)indoline

DownStream

5-Nitrosalicylaldehyde
Spiro[2H-1-benzopyran-2,2'-[2H]indole],1',3'-dihydro-1',3',3'-trimethyl-6-nitro-

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A new pulsatile flow visualization method using a photochromic dye with application to Doppler ultrasound.

Ann. Biomed. Eng. 14(3) , 203-18, (1986)

A nonintrusive method for the visualization of pulsatile flow velocity profiles is described. The method is based on the use of a photochromic dye that is added to the fluid being studied and a nitrog...

Mast cells involvement in the inflammation and fibrosis development of the TNBS-induced rat model of colitis.

Scand. J. Gastroenterol. 37(3) , 330-7, (2002)

Mast cells have been implicated in chronic inflammatory conditions resulting in fibrosis, such as Crohn disease. However, a link between inflammation, fibrosis and mast cells has not been demonstrated...

Direct structural determination of conformations of photoswitchable molecules by laser desorption-electron diffraction.

Angew. Chem. Int. Ed. Engl. 49(37) , 6524-7, (2010)

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