5-bromo-1,3,6-trimethylpyrimidine-2,4(1H,3H)-dione

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Names

[ CAS No. ]:
15018-59-4

[ Name ]:
5-bromo-1,3,6-trimethylpyrimidine-2,4(1H,3H)-dione

[Synonym ]:
5-bromo-1,3,6-trimethyl-1H-pyrimidine-2,4-dione
2,4(1H,3H)-Pyrimidinedione,5-bromo-1,3,6-trimethyl
Uracil,5-bromo-1,3,6-trimethyl
5-Brom-1,3,6-trimethyl-1H-pyrimidin-2,4-dion
5-Bromo-1,3,6-trimethyluracil
1,3,6-Trimethyl-5-brom-uracil
5-Brom-1,3,6-trimethyl-uracil
5-bromo-1,3,6-trimethylpyrimidine-2,4(1H,3H)-dione

Chemical & Physical Properties

[ Density]:
1.605g/cm3

[ Boiling Point ]:
254.5ºC at 760mmHg

[ Molecular Formula ]:
C7H9BrN2O2

[ Molecular Weight ]:
233.06300

[ Flash Point ]:
107.7ºC

[ Exact Mass ]:
231.98500

[ PSA ]:
44.00000

[ LogP ]:
0.15490

[ Vapour Pressure ]:
0.0172mmHg at 25°C

[ Index of Refraction ]:
1.565

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YQ9300000
CHEMICAL NAME :
Uracil, 5-bromo-1,3,6-trimethyl-
CAS REGISTRY NUMBER :
15018-59-4
BEILSTEIN REFERENCE NO. :
0144941
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H9-Br-N2-O2
MOLECULAR WEIGHT :
233.09
WISWESSER LINE NOTATION :
T6NVNVJ A1 C1 EE F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
252 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,471,1972

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,3,6-trimethyluracil
  • 5-bromo-6-bromomethyl-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

DownStream

  • 1,3-dimethyl-6-(phenylsulfanylmethyl)pyrimidine-2,4-dione
  • 1,3-dimethyl-5-phenylthio-6-phenylthiomethyluracil
  • 4(3H)-Pyrimidinone,2-amino-5-bromo-6-methyl-
  • 1,3,6-trimethyluracil

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Reactions of diazines with nucleophiles--IV. The reactivity of 5-bromo-1,3,6-trimethyluracil with thiolate ions--substitution versus X-philic versus single electron transfer reactions.

Bioorg. Med. Chem. 3(7) , 891-7, (1995)

Reaction of 5-Bromo-1,3,6-trimethyluracil (1) with alkylthiolate (propane-1-, toluene-alpha-, allyl-, etc.) ions under phase transfer catalytic conditions follows nucleophilic substitution and X-phili...


More Articles

Related Compounds

  • 5-Bromo-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
  • 1,3,6-trimethyluracil
  • 5-methoxy-1,3,6-trimethylpyrimidine-2,4-dione
  • 5-hydroxy-1,3,6-trimethylpyrimidine-2,4-dione
  • 5-Bromo-1,3-dimethyl-6-[(2,2,2-trifluoroethyl)amino]-2,4(1H,3H)-pyrimidinedione
  • 5-BROMO-1-(2,3-DIBROMOPROPYL)PYRIMIDINE-2,4(1H,3H)-DIONE
  • Acetamide, 2-(cyclopropylamino)-N-[(tetrahydro-2-furanyl)methyl]-
  • 2-(cyclopropylamino)-N-(2-ethylphenyl)acetamide
  • N-benzyl-2-(cyclopropylamino)-N-methylacetamide
  • 2-(Cyclopropylamino)-1-(2,6-dimethylpiperidin-1-yl)ethanone
  • 4-(3-(3-(Trifluoromethyl)phenyl)-1H-1,2,4-triazol-5-yl)piperidine
  • 2-bromo-N-(5-tert-butyl-1H-pyrazol-3-yl)-5-chloropyrimidin-4-amine
  • 3-chloro-4-iodo-1H-pyrazolo[3,4-b]pyridine
  • 2-chloro-1-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrole-3-carboxylic acid
  • 5-{[9-(2-Isobutoxybenzyl)-3,9-diazaspiro[5.5]undec-3-yl]carbonyl}pyridin-2(1h)-one
  • methyl 5-bromo-1-methyl-1H-pyrrole-3-carboxylate
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