Naphtho[2,3-d]-1,3-dioxole-6-carboxylicacid,5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-,2-ethylhydrazide, (5R,6R,7R,8R)-
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Names
[ CAS No. ]:
1508-45-8
[ Name ]:
Naphtho[2,3-d]-1,3-dioxole-6-carboxylicacid,5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-,2-ethylhydrazide, (5R,6R,7R,8R)-
[Synonym ]:
Proreside
SP-I 77
Proresid
Podophyllinic acid 2-ethylhydrazide
Propesid
Chemical & Physical Properties
[ Density]:
1.301g/cm3
[ Boiling Point ]:
619.6ºC at 760mmHg
[ Molecular Formula ]:
C24H30N2O8
[ Molecular Weight ]:
474.50400
[ Flash Point ]:
328.5ºC
[ Exact Mass ]:
474.20000
[ PSA ]:
127.74000
[ LogP ]:
2.26720
[ Vapour Pressure ]:
3.26E-16mmHg at 25°C
[ Index of Refraction ]:
1.587
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TP8800000
- CHEMICAL NAME :
- Podophyllic acid, 2-ethylhydrazide
- CAS REGISTRY NUMBER :
- 1508-45-8
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C24-H30-N2-O8
- MOLECULAR WEIGHT :
- 474.56
- WISWESSER LINE NOTATION :
- T C566 DO FO EH&&TJ JQ K1Q LVMM2 MR CO1 DO1 EO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1467,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,363,1970