Retigabine

Suppliers

Names

[ CAS No. ]:
150812-12-7

[ Name ]:
Retigabine

[Synonym ]:
N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester
Retigabine
Carbamic acid, N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-, ethyl ester
Trobalt
[2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester
2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene
N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
Ethyl (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)carbamate
Ezogabine
D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
Ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate
Potiga
EINECS 200-835-2

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
430.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H18FN3O2

[ Molecular Weight ]:
303.331

[ Flash Point ]:
213.9±28.7 °C

[ Exact Mass ]:
303.138306

[ PSA ]:
76.38000

[ LogP ]:
0.81

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.656

[ Storage condition ]:
room temp

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319-H413

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
T,N,Xn,F,Xi

[ Risk Phrases ]:
23-25-50/53-36-20/21/22-11

[ Safety Phrases ]:
45-60-61-36/37-16-26

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.

Epilepsia 55(4) , 601-8, (2014)

A NaV β1(C121W) mouse model of human genetic epilepsy has enhanced neuronal excitability and temperature sensitivity attributed to a decreased threshold for action potential firing in the axon initial...

Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel.

Expert Opin. Drug Saf. 12(6) , 847-55, (2013)

Complex-partial seizures are frequently resistant to antiepileptic therapy. Two new medications with mechanisms of action novel within the antiepileptic class have recently received approval for the a...

Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.

Clin. Ther. 34(9) , 1845-56.e1, (2012)

Ezogabine, also known as retigabine, is a recently approved anticonvulsant medication with a novel mechanism of action. It activates low-threshold voltage-gated potassium channels, leading to hyperpol...


More Articles

Related Compounds

  • N-Acetyl Retigabine
  • Retigabine Impurity 4
  • Retigabine N-β-D-Glucoside
  • Retigabine dihydrochloride
  • Retigabine N-β-D-Glucuronide
  • Retigabine-d4 Dihydrochloride
  • 2-(4-tert-butylphenyl)-5-nitro-1H-benzimidazole
  • 3-[(Dimethyl-1,3-thiazol-2-yl)carbamoyl]propanoic acid hydrochloride
  • 2-Methyl-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester
  • 2-Morpholin-4-yl-thiazol-4-one hydrochloride
  • 1-(4-Amino-1,2,5-oxadiazol-3-yl)ethan-1-one hydrate
  • 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-N-methylcyclopentan-1-amine
  • 5-Bromo-8-fluoro-1,2,3,4-tetrahydroisoquinoline
  • 1-Naphthalenemethanamine, 2-[(2-methylphenyl)methoxy]-N-[2-(2-pyridinyloxy)ethyl]-
  • 2-(4-Fluoro-2-nitrophenyl)propanoic acid
  • Isovaline, 2a(2)-methoxy-N-(4-methylphenyl)-, methyl ester
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