L-Tyrosine,N-[(phenylmethoxy)carbonyl]-L-valyl-, methyl ester

Names

[ CAS No. ]:
15149-72-1

[ Name ]:
L-Tyrosine,N-[(phenylmethoxy)carbonyl]-L-valyl-, methyl ester

[Synonym ]:
methyl 3-(4-hydroxyphenyl)-2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoate

Chemical & Physical Properties

[ Density]:
1.214 g/cm3

[ Boiling Point ]:
654.7ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₈N₂O₆

[ Molecular Weight ]:
428.47800

[ Flash Point ]:
349.7ºC

[ Exact Mass ]:
428.19500

[ PSA ]:
113.96000

[ LogP ]:
3.32530

[ Vapour Pressure ]:
9.66E-18mmHg at 25°C

[ Index of Refraction ]:
1.562

MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Z-Val-OH
H-Tyr-OMe
H-Tyr-OMe.HCl
Methanol
N-[N-[(benzyloxy)carbonyl]-L-valyl]-L-tyrosinohydrazide
Z-Val-Tyr-OH
2,2-Dimethoxypropane
Z-Val-OSu
Z-Val-ONp

DownStream

Articles

Antihypertensive mechanism of the dipeptide Val-Tyr in rat aorta.

Peptides 29 , 261-267, (2008)

Antihypertensive peptides received much interest over the last decade. These peptides are known to be angiotensin converting enzyme (ACE) inhibitors in vitro, but the actual antihypertensive mechanism...

Combined administration of captopril with an antihypertensive Val-Tyr di-peptide to spontaneously hypertensive rats attenuates the blood pressure lowering effect.

Life Sci. 79 , 2492-2498, (2006)

Some di-peptides have been proven to exert an antihypertensive effect in mild-hypertensive subjects. The aim of this study was to clarify whether combined administration of an ACE inhibitor, captopril...

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