Edoxudine

Names

[ Name ]:
Edoxudine

[Synonym ]:
5-Ethyl-2'-deoxyuridine
2'-deoxy-5-ethyluridine
EUdR Edoxudine
edu
edoxudin
Etudr
5-Ethyl-durd
aedurid
5-ethyldeoxyuridine
EDOXUDINE

Chemical & Physical Properties

[ Density]:
1.389 g/cm3

[ Melting Point ]:
152-153°

[ Molecular Formula ]:
C₁₁H₁₆N₂O₅

[ Molecular Weight ]:
256.25500

[ Exact Mass ]:
256.10600

[ PSA ]:
104.55000

[ Index of Refraction ]:
1.569

[ Storage condition ]:
?20°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7500000

CHEMICAL NAME :: Uridine, 2'-deoxy-5-ethyl-

CAS REGISTRY NUMBER :: 15176-29-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H16-N2-O5

MOLECULAR WEIGHT :: 256.29

WISWESSER LINE NOTATION :: T6NVMVJ F2 A- BT5OTJ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rabbit Kidney

DOSE/DURATION :: 200 mg/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 24,1073,1975

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YU7500000

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

5-Ethynyl-2'-deoxyuridine
5-vinyl-2'-deoxyuridine
1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil
5-Ethyluracil
Thymidine
5-Ethyluridine
5-ethyl-2,2'-anhydrouridine
idoxuridine

DownStream

1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-ethylpyrimidine-2,4-dione
5-ethyl-1-[(2R,4S,5R)-5-(hydroxymethyl)-4-iodooxolan-2-yl]pyrimidine-2,4-dione
5-ethyl-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione

Articles

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.

Antimicrob. Agents Chemother. 51 , 2028-34, (2007)

Herpes B virus (B virus [BV]) is a macaque herpesvirus that is occasionally transmitted to humans where it can cause rapidly ascending encephalitis that is often fatal. To understand the low susceptib...

Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells.

J. Neurosci. 32(43) , 15066-75, (2012)

Oligodendrocyte progenitor cells (OPCs) persist in human white matter, yet the mechanisms by which they are maintained in an undifferentiated state are unknown. Human OPCs differentially express prote...

An in vitro study of ophthalmic antiviral agent toxicity on rabbit corneal epithelium.

Antiviral Res. 9(4) , 263-72, (1988)

Using an in vitro system we measured the corneal epithelial cytotoxicity and the antiviral activity of the antiviral agents idoxuridine (IDU), trifluridine (TFT), ethyldeoxyuridine (EDU), and (E)-5-(2...

Edoxudine
edoxudine
Methyl 4-fluoro-4-methoxybut-2-ynoate
Methyl 4-ethyl-6,6-difluorohex-2-ynoate
Methyl 3-{bicyclo[4.1.0]heptan-3-yl}prop-2-ynoate
2-{[(9H-fluoren-9-yl)methoxy]carbonyl}-6-oxo-1,2-diazinane-4-carboxylic acid
6-Hydroxy-2-(2-methylbutyl)pyrimidine-4-carboxylic acid
(2R)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxypropanamido]propanoic acid
dimethyl({3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-6-yl}methyl)amine dihydrochloride
dimethyl({3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-6-yl}methyl)amine
3-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]acetyl}-1,3-thiazolidine-4-carboxylic acid
3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-oxo-4-[4-(propan-2-ylsulfanyl)piperidin-1-yl]butanoic acid

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