Dp44mT

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Names

[ CAS No. ]:
152095-12-0

[ Name ]:
Dp44mT

[Synonym ]:
2-(Di-2-pyridinylmethylene)-N,N-dimethylhydrazinecarbothioamide
2-(dipyridin-2-ylmethylidene)-N,N-dimethylhydrazinecarbothioamide
Hydrazinecarbothioamide,2-(di-2-pyridinylmethylene)-N,N-dimethyl
Iron Chelator,Dp44mT
Hydrazinecarbothioamide, 2-(di-2-pyridinylmethylene)-N,N-dimethyl-
2,N-dimethylsemicarbazone
Dp44mT

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
438.4±43.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₅N₅S

[ Molecular Weight ]:
285.367

[ Flash Point ]:
218.9±28.2 °C

[ Exact Mass ]:
285.104828

[ PSA ]:
92.54000

[ LogP ]:
1.21

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.

Oncotarget 6 , 10374-98, (2015)

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that 14C-Dp44mT enters and targets cells through a carrier/receptor-me...

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

Oncotarget 6 , 8851-74, (2015)

N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that plays a key role in regulating signaling pathways involved in mediating cancer cell invasion and migration, including t...

Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells.

Mol. Cell. Endocrinol. 407 , 74-84, (2015)

High levels of plasma free fatty acid are thought to contribute to the loss of pancreatic beta-cells in type 2 diabetes. In particular, saturated fatty acid such as palmitate or stearate can induce ap...

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