SB202190 (FHPI)

Suppliers

Names

[ Name ]:
SB202190 (FHPI)

[Synonym ]:
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-2H-imidazol-2-yl)phenol
4-[4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
4-[5-(4-Fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
FHPI
4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
Phenol, 4-[5-(4-fluorophenyl)-4-(4-pyridinyl)-1H-imidazol-2-yl]-
SB202190
SB 202190

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
565.7±50.0 °C at 760 mmHg

[ Melting Point ]:
240-243℃

[ Molecular Formula ]:
C₂₀H₁₄FN₃O

[ Molecular Weight ]:
331.343

[ Flash Point ]:
295.9±30.1 °C

[ Exact Mass ]:
331.112091

[ PSA ]:
61.80000

[ LogP ]:
5.00

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.653

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29333990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Fluoro-N-methoxy-N-methylbenzamide
4-(tert-butyldimethylsilyloxymethyl)pyridine
4-Picoline
1-(4-Fluorophenyl)-2-(pyridin-4-yl)ethanone
4-FLUOROBENZOYL CHLORIDE
4-hydroxybenzaldehyde
2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone

DownStream

Articles

Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro.

Acta Pharmacol. Sin. 36(4) , 517-27, (2015)

To investigate the effects of physalin B insolated from Physalis divericata on human colon cancer cells in vitro and its anticancer mechanisms.Human HCT116 colon cancer cell line was tested. Cell viab...

Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes.

Stem Cells Dev. 23(20) , 2435-42, (2014)

Adhesion of Plasmodium falciparum-infected red blood cells (iRBC) to human erythrocytes (i.e. rosetting) is associated with severe malaria. Rosetting results from interactions between a subset of vari...

Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells.

J. Immunol. 193(12) , 6135-43, (2014)

Recent studies suggest a role for autophagy in the secretion of IL-1 cytokines regulating the development of inflammatory diseases. The antimalarial drug and autophagy/lysosome inhibitor chloroquine (...

(3R,4R)-3-tert-Butoxycarbonylamino-4-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester
cis-3-tert-Butoxycarbonylamino-4-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester
trans-3-tert-Butoxycarbonylamino-4-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester
(3R,4S)-3-tert-Butoxycarbonylamino-4-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester
3-tert-Butoxycarbonylamino-piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester
trans-3-tert-Butoxycarbonylamino-piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester
(3R,4S)-3-tert-Butoxycarbonylamino-piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester
cis-(4-Hydroxymethyl-piperidin-3-yl)-carbamic acid tert-butyl ester
trans-(4-Hydroxymethyl-piperidin-3-yl)-carbamic acid tert-butyl ester
(3S,5R)-N-(1-Benzyl-5-hydroxy-piperidin-3-yl)-2,2,2-trifluoro-acetamide

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