SB203580

Suppliers

Names

[ Name ]:
SB203580

[Synonym ]:
PB 203580
4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine
RWJ 64809
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(pyridin-4-yl)imidazole
4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridyl)-1H-imidazole
MFCD00922198
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
4-{4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(pyridin-4-yl)-1H-imidazole
Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-
Pyridine,4-(5-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)
SB 203580
SB203580
SB-203580

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
615.6±55.0 °C at 760 mmHg

[ Melting Point ]:
249 - 250ºC

[ Molecular Formula ]:
C₂₁H₁₆FN₃OS

[ Molecular Weight ]:
377.435

[ Flash Point ]:
326.1±31.5 °C

[ Exact Mass ]:
377.099823

[ PSA ]:
77.85000

[ LogP ]:
4.10

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.715

[ Storage condition ]:
−20°C

[ Stability ]:
-200C

[ Water Solubility ]:
DMSO: 50 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22;R41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2818200000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-[4-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-5-yl]pyridine
4-Pyridinemethanol
4-FLUOROBENZOYL CHLORIDE
4-Fluoro-N-methoxy-N-methylbenzamide
4-(tert-butyldimethylsilyloxymethyl)pyridine
2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone

DownStream

Customs

[ HS Code ]: 2818200000

Articles

Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells.

PLoS ONE 10 , e0125903, (2015)

Previously, we demonstrated that progesterone (P4) at physiologic levels (5-500 nM) inhibited proliferation in cultured rat aortic smooth muscle cells (RASMCs) through a P4 receptor (PR)-dependent pat...

Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling.

Nucleic Acids Res. 42(18) , 11349-62, (2014)

MEF2 plays a profound role in the regulation of transcription in cardiac and skeletal muscle lineages. To define the overlapping and unique MEF2A genomic targets, we utilized ChIP-exo analysis of card...

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.

Brain 137(Pt 8) , 2193-209, (2014)

Accumulating evidence suggests that spinal cord astrocytes play an important role in neuropathic pain sensitization by releasing astrocytic mediators (e.g. cytokines, chemokines and growth factors). H...

2-Bromo-1-(4-chloro-2,3-difluorophenyl)ethan-1-one
3H-Spiro[furo[2,3-C]pyridine-2,4'-piperidine]
2-(Iodomethyl)-6-methyloxane
3-Bromo-5-(1-hydroxy-1-methylethyl-d6)-pyridine
1-[3-(Benzyloxy)propyl]-1H-1,2,4-triazol-3-amine
Methyl 2-amino-5-(benzyloxy)pentanoate
1H-Pyrazole-5-carbonitrile, 1-ethyl-4-hydroxy-
5-(Benzyloxy)-2-{[(benzyloxy)carbonyl]amino}pentanoic acid
2-Amino-5-(benzyloxy)pentanamide
5-(Phenylmethoxy)-D-norvaline

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