Azetidine, 1-nitroso-

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Names

[ Name ]:
Azetidine, 1-nitroso-

[Synonym ]:
N-Nitrosazetidine
Nitroso-azetidin [German]
AZETIDINE,1-NITROSO
N-Nitrosoazetidine
N-Nitrosotrimethyleneimine
1-Nitroso-azetidin
Nitroso-azetidin
Nitrosotrimethyleneimine
N-Nitroso-azetidin
1-nitroso-azetidine
Nitrosoazetidine

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
201.7ºC at 760mmHg

[ Molecular Formula ]:
C₃H₆N₂O

[ Molecular Weight ]:
86.09250

[ Flash Point ]:
75.8ºC

[ Exact Mass ]:
86.04800

[ PSA ]:
32.67000

[ LogP ]:
0.31140

[ Vapour Pressure ]:
0.432mmHg at 25°C

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM4375000

CHEMICAL NAME :: Azetidine, 1-nitroso-

CAS REGISTRY NUMBER :: 15216-10-1

BEILSTEIN REFERENCE NO. :: 0106316

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H6-N2-O

MOLECULAR WEIGHT :: 86.11

WISWESSER LINE NOTATION :: T4NTJ ANO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 198 mg/kg/17W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg/48D-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 4 gm/kg/50W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 920 mg/kg/46D-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3444 mg/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 4306 mg/kg/64W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 250 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,21,1979

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Azetidine
Nitrous acid, propylester
Butyl nitrite

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Azetidine, 1-acetyl-3,3-diethyl- (7CI)
Azetidine, 1,1'-azobis-(9CI)
Azetidine,1-(1,1-dimethylethyl)-3-methyl-
Azetidine, 1-(1,1-dimethylethyl)-
Azetidine,1-acetyl-2-methylene-4-phenyl- (9CI)
azetidine-1-carbothioic acid anilide
1-(1,4-Cyclohexadien-1-yl)-1-propanone
Methyl 2-[1-[(2S)-2-(2,4-dioxo-1H-quinazolin-3-yl)-4-methylsulfanylbutanoyl]piperidin-4-yl]acetate
1-[2-[(Tert-butoxycarbonyl)amino]ethyl]-5-methyl-1H-imidazole-4-carboxylic acid ethyl ester
2-(2-Bromoethyl)-2H-tetrazole
4-(5-methyl-1H-imidazol-4-yl)-1-piperidin-4-ylpiperidine;hydrochloride
tert-butyl 4-[4-(5-methyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]piperidine-1-carboxylate
2-bromo-N-(2-(6-fluoro-3-methyl-2,2-dioxidobenzo[c][1,2,5]thiadiazol-1(3H)-yl)ethyl)benzamide
N-[2-(6-fluoro-3-methyl-2,2-dioxo-1,3-dihydro-2lambda6,1,3-benzothiadiazol-1-yl)ethyl]-3-(4-oxo-3,4-dihydroquinazolin-3-yl)propanamide
2-Bromo-1,1-difluoropropane
5-(4-(Methoxymethyl)phenyl)-3-(piperazin-1-yl)pyridazine

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