Azetidine, 1-nitroso-

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Names

[ CAS No. ]:
15216-10-1

[ Name ]:
Azetidine, 1-nitroso-

[Synonym ]:
N-Nitrosazetidine
Nitroso-azetidin [German]
AZETIDINE,1-NITROSO
N-Nitrosoazetidine
N-Nitrosotrimethyleneimine
1-Nitroso-azetidin
Nitroso-azetidin
Nitrosotrimethyleneimine
N-Nitroso-azetidin
1-nitroso-azetidine
Nitrosoazetidine

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
201.7ºC at 760mmHg

[ Molecular Formula ]:
C3H6N2O

[ Molecular Weight ]:
86.09250

[ Flash Point ]:
75.8ºC

[ Exact Mass ]:
86.04800

[ PSA ]:
32.67000

[ LogP ]:
0.31140

[ Vapour Pressure ]:
0.432mmHg at 25°C

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CM4375000
CHEMICAL NAME :
Azetidine, 1-nitroso-
CAS REGISTRY NUMBER :
15216-10-1
BEILSTEIN REFERENCE NO. :
0106316
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C3-H6-N2-O
MOLECULAR WEIGHT :
86.11
WISWESSER LINE NOTATION :
T4NTJ ANO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
198 mg/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg/48D-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
4 gm/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
920 mg/kg/46D-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3444 mg/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
4306 mg/kg/64W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
250 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,21,1979

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Precursor & DownStream

Precursor

  • Azetidine
  • Nitrous acid, propylester
  • Butyl nitrite

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • Azetidine, 1-acetyl-3,3-diethyl- (7CI)
  • Azetidine, 1,1'-azobis-(9CI)
  • Azetidine,1-(1,1-dimethylethyl)-3-methyl-
  • Azetidine, 1-(1,1-dimethylethyl)-
  • Azetidine,1-acetyl-2-methylene-4-phenyl- (9CI)
  • azetidine-1-carbothioic acid anilide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-Amino-2-(3-fluorophenyl)-2-methylpropan-1-ol
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-Pyrrolidinecarboxamide, N-[(4-methoxyphenyl)sulfonyl]-, (2S)-
  • tert-Butyl-DL-alanine