Nebivolol hydrochloride

Suppliers

Names

[ Name ]:
Nebivolol hydrochloride

[Synonym ]:
2H-1-Benzopyran-2-ethanaminium, 6-fluoro-N-[(2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]-3,4-dihydro-β-hydroxy-, chloride, (βR,2S)- (1:1)
(S,R,R,R)-nebivolol hydrochloride
(2R)-2-[(2R)-6-Fluoro-3,4-dihydro-2H-chromen-2-yl]-N-{(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl}-2-hydroxyethanaminium chloride
Nebivolol hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
600.5ºC at 760 mmHg

[ Melting Point ]:
220-222ºC

[ Molecular Formula ]:
C₂₂H₂₆ClF₂NO₄

[ Molecular Weight ]:
441.896

[ Flash Point ]:
316.9ºC

[ Exact Mass ]:
441.151855

[ PSA ]:
70.95000

[ LogP ]:
3.55650

[ Vapour Pressure ]:
2.88E-15mmHg at 25°C

[ Storage condition ]:
Desiccate at RT

[ Water Solubility ]:
DMSO: ≥20mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
3077

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design, development and permeation studies of nebivolol hydrochloride from novel matrix type transdermal patches.

Adv. Biomed. Res. 2 , 62, (2013)

Nebivolol hydrochloride is a third generation β-blocker with highly selective β1-receptor antagonist with antihypertensive properties having plasma half life of 10 h and 12% oral bioavailability. The ...

Simultaneous estimation of amlodipine besylate and nebivolol hydrochloride in tablet dosage forms by reverse phase-high-performance liquid chromatographic using ultraviolet detection.

Pharm. Methods 2 , 9-14, (2013)

The present study aimed to develop and validate the simultaneous estimation of amlodipine and nebivolol in tablet dosage forms.An isocratic reversed phase high-performance liquid chromatographic (HPLC...

Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.

FASEB J. 25 , 4486-97, (2011)

β-Adrenoceptor antagonists differ in their degree of partial agonism. In vitro assays have provided information on ligand affinity, selectivity, and intrinsic efficacy. However, the extent to which th...

Nebivolol hydrochloride
NEBIVOLOL HYDROCHLORIDE
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(R,S,S,S)-Nebivolol Hydrochloride
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4-(4-Bromo-2-hydroxyphenyl)but-3-en-2-one
2-(2-{4-[(pentan-3-yl)amino]-1H-pyrazol-1-yl}ethoxy)ethan-1-ol
2-[1-(2,5-Difluorophenyl)cyclobutyl]ethan-1-amine
2-[3-Chloro-4-(trifluoromethoxy)phenyl]propanal
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