α-Methyltryptophan

Names

[ CAS No. ]:
153-91-3

[ Name ]:
α-Methyltryptophan

[Synonym ]:
Tryptophan, α-methyl-
H-DL-(ME)TRP-OH
α-Methyltryptophan
H-a-Me-DL-Trp-OH
A-methyl-dl-tryptophan
MFCD00038416
(S)-A-METHYLTRYPTOPHAN

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
444.0±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₄N₂O₂

[ Molecular Weight ]:
218.25

[ Flash Point ]:
222.3±25.9 °C

[ Exact Mass ]:
218.105530

[ PSA ]:
79.11000

[ LogP ]:
1.39

[ Appearance of Characters ]:
crystalline | light yellow

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.675

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

5-indol-3-ylmethyl-5-methyl-imidazolidine-2,4-dione
Indole-3-acetone

DownStream

(2R)-2-amino-3-(1H-indol-3-yl)-2-methylpropanoic acid
α-Methyl-L-tryptophan
methyl N-[1-(1H-indol-3-yl)propan-2-yl]carbamate

Articles

α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies.

Biomark. Med. 5(5) , 577-84, (2011)

Of several molecular probes used in PET, only α-[(11)C]-methyl-L-tryptophan (AMT) is able to pinpoint the epileptic focus itself in the interictal state, by revealing a focus of increased AMT uptake, ...

α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.

Biomark. Med. 5(5) , 567-75, (2011)

The purpose of this paper is to discuss the mechanisms of α-[(11)C]methyl-L-tryptophan (AMT) PET as an in vivo biomarker for detection of epileptogenic cortex. AMT was originally designed as a tracer ...

Measuring effects of MDMA (ecstasy) abuse on the rate of cerebral serotonin synthesis.

J. Neurochem. 131(5) , 541-5, (2014)

(+)-L-methyl α-methyltryptophan hydrochloride
DL-α-METHYLTRYPTOPHAN METHYL ESTER HYDROCHLORIDE
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyltryptophan
α-Methyl-L-tryptophan
α-N-(Trifluoroacetyl)-4-(trifluoromethyl)-L-histidine methyl ester
α-(4-methylbenzyl)naphthalene
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-[6-(Pyrrolidin-3-yloxy)pyridin-2-yl]morpholine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide