Omuralide

Suppliers

Names

[ Name ]:
Omuralide

[Synonym ]:
(3S,4S,7R,8S)-8-Hydroxy-3-isopropyl-7-methyl-2-oxa-5-azaspiro[3.4]octane-1,6-dione
6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-(1-hydroxy-2-methylpropyl)-4-methyl-
Tri-p-tolylstibine
Tri-p-tolylantimony
Clasto-Lactacystin Beta-lactone
2-Oxa-5-azaspiro[3.4]octane-1,6-dione, 8-hydroxy-7-methyl-3-(1-methylethyl)-, (3S,4S,7R,8S)-
1-(1-Hydroxy-2-methylpropyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
Stibine,tri-p-tolyl
5,6,7,12,6'-pentamethoxy-2-methyl-berbam-1'-ene

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
462.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅NO₄

[ Molecular Weight ]:
213.230

[ Flash Point ]:
233.7±28.7 °C

[ Exact Mass ]:
213.100113

[ PSA ]:
75.63000

[ LogP ]:
-1.40

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.534

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(3R,4S)-(-)-1-BENZYL-3,4-PYRROLIDINDIOL
(1R,4R,5S)-1-((S)-1-hydroxy-2-methylpropyl)-2-(4-methoxybenzyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
(2R,3R,4R,1'S)-(+)-3-hydroxy-2-(1-hydroxy-2-methyl-propyl)-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester
(2R)-2-Amino-3-hydroxy-4-methylpentansaeure-methylester

DownStream

Articles

Proteasome inhibitor differentially regulates expression of the major immediate early genes of human cytomegalovirus in human central nervous system-derived cell lines.

Virus Res. 142(1-2) , 68-77, (2009)

Proteasome inhibitor, which inhibits NF-kappaB activation, has been reported to activate c-Jun N-terminal kinase (JNK)-c-Jun pathway. In this study, we investigated the effects of proteasome inhibitor...

Turnover of StAR protein: roles for the proteasome and mitochondrial proteases.

Mol. Cell. Endocrinol. 265-266 , 51-8, (2007)

Steroidogenic acute regulatory protein (StAR) is a mitochondrial protein essential for massive synthesis of steroid hormones in the adrenal and the gonads. Our studies suggest that once synthesized on...

Targeting of a chlamydial protease impedes intracellular bacterial growth.

PLoS Pathog. 7(9) , e1002283, (2011)

Chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministac...

OMURALIDE
α-Methyl OMuralide