Abiraterone Acetate

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Names

[ CAS No. ]:
154229-18-2

[ Name ]:
Abiraterone Acetate

[Synonym ]:
17-(3-pyridyl)-5,16-androstadien-3beta-acetate
Abiraterone acetate
Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)-
Zytiga
(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate
(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate
Abiraterone (acetate)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
506.7±50.0 °C at 760 mmHg

[ Melting Point ]:
127-130°C

[ Molecular Formula ]:
C26H33NO2

[ Molecular Weight ]:
391.546

[ Flash Point ]:
260.2±30.1 °C

[ Exact Mass ]:
391.251129

[ PSA ]:
39.19000

[ LogP ]:
6.55

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360-H372

[ Precautionary Statements ]:
P201-P260-P280-P308 + P313

[ Target Organs ]:
Endocrine system

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
BV7992100

[ HS Code ]:
2933399090

Precursor & DownStream

Precursor

  • (3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)
  • 3-Pyridylboronic acid
  • Ethanoic anhydride
  • Abiraterone
  • Acetyl chloride
  • 3-Bromopyridine
  • [10,13-dimethyl-17-[(4-methylphenyl)sulfonylhydrazinylidene]-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] acetate
  • Dehydroepiandrosterone acetate
  • 3-(Diethylboryl)pyridine
  • Dehydroepiandrosterone

DownStream

  • Abiraterone

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy.

J. Clin. Oncol. 28(9) , 1481-8, (2010)

Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the enzyme catalyst for two essential steps in androgen biosynthesis. In castration-resistant prostate cancers (CRPCs),...

Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate.

J. Clin. Oncol. 28(9) , 1489-95, (2010)

The principal objective of this trial was to evaluate the antitumor activity of abiraterone acetate, an oral, specific, irreversible inhibitor of CYP17 in docetaxel-treated patients with castration-re...

Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer.

J. Clin. Oncol. 28(9) , 1496-501, (2010)

Persistence of ligand-mediated androgen receptor signaling has been documented in castration-resistant prostate cancers (CRPCs). Abiraterone acetate (AA) is a potent and selective inhibitor of CYP17, ...


More Articles

Related Compounds

  • Abiraterone Acetate Dimer Impurity
  • Abiraterone decanoate
  • Glutinol acetate
  • Menthyl acetate
  • chrysanthenyl acetate
  • Germanicol acetate
  • 2-Cycloheptylacetaldehyde
  • Ethyl 3-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate
  • 4-(9-Anthracenyl)-N,N-bis[4-(9-anthracenyl)phenyl]benzenamine
  • 6-Bromo-1-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinoline
  • 2-Oxo-2-(5,6,7,8-tetrahydronaphthalen-1-yl)acetic acid
  • 2'-Fluoro-2-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid
  • Dimethyl(N,N,N',N'-tetramethylethylenediamine)nickel(II)
  • Methyl 6-(2,4-Difluorophenoxy)nicotinate
  • 2-(3,4-dihydro-2H-chromen-4-ylsulfanyl)acetic acid
  • 4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-fluoroaniline
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