Echistatin

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Names

[ CAS No. ]:
154303-05-6

[ Name ]:
Echistatin

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁₇H₃₄₁N₇₁O₇₄S₉

[ Molecular Weight ]:
5417.0

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor.

J. Pharmacol. Exp. Ther. 283(2) , 843-53, (1997)

Echistatin is a 49-amino-acid peptide belonging to the family of disintegrins that are derived from snake venoms and are potent inhibitors of platelet aggregation and cell adhesion. Integrin alphavbet...

Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction.

Circulation 96(6) , 1809-18, (1997)

Platelet interaction with endothelium plays an important role in the pathophysiology of coronary microcirculation. We assessed the role of the vitronectin receptor (integrin alpha(v)beta3) in platelet...

Structural analysis of a biologically active echistatin analogue des(46-49)-[Ala8,37]-echistatin gamma with three disulfide bonds by 2D-NMR and computer graphics.

Biochem. Biophys. Res. Commun. 220(2) , 246-54, (1996)

An echistatin analogue, designated as des(46-49)-[Ala8,37]-echistatin gamma, was synthesized chemically by solid-phase peptide synthesis. The analogue was made by replacing Cys8 and Cys37 residues wit...